Golestan University of Medical Sciences Repository

Clinical application of ultrasound for preparation of 99mTc-sestamibi complex

Doroudi, A. and Erfani, M. and Norouzi, B. and Saadati, S.M. and Kiasat, A. and Ahmadi, F. and Etesami, B. and Baghersad, M.H. (2015) Clinical application of ultrasound for preparation of 99mTc-sestamibi complex. Annals of Nuclear Medicine, 29 (3). pp. 295-301.

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Abstract

Objective: The main aim of this investigation is the clinical application of ultrasound irradiation technique as an alternative method to reconstitute sestamibi kits in comparison of water boiling bath method. Methods: The 740–3700 MBq (20–100 mCi) 99mTc-MIBI (sestamibi) complex samples were prepared due to ultrasound irradiation technique or boiled water bath method as a standard method. Twenty patients (8 men and 12 women; age range 30–72, median 52.45 years) have been referred to Golestan hospital for myocardial perfusion imaging (MPI). The subjects have been divided randomly into group A (3 men, 7 women, age range 36–67, median 51.7 years) and group B (5 men, 5 women, age range 30–72, median 50.3 years), respectively. The 99mTc-MIBI radiopharmaceuticals have been prepared by Ultrasound irradiation technique administrated to group A and 99mTc-MIBI complex samples due to the boiled water bath technique administrated to the other group. For all patients, the 2-day stress/rest MPI protocol was performed. Results: The radio-HPLC and TLC studies have indicated that the 99mTc-MIBI complex samples with good yields could be prepared successfully due to new developed technique. The scintigraphy imaging studies have demonstrated that the 99mTc-sestamibi prepared due to the above-mentioned modalities shows very identical biodistribution in the heart, thyroid, lung, liver, gallbladder, kidneys, stomach, large intestine and bladder of the subjects. Any unexpected accumulation of radiotracer samples have not been observed in our approach. Conclusions: The ultrasound irradiation technique is convenient and sufficient method to prepare 99mTc-sestamibi. It can be recommended as an alternative method to reconstitute sestamibi kits particularly in emergency situations to reduce potentially medical risk by avoiding any delay in acute therapy for myocardial infarction. © 2014, The Japanese Society of Nuclear Medicine.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: methoxy isobutyl isonitrile technetium tc 99m; radiopharmaceutical agent; water, adult; aged; drug formulation; female; gallbladder; heart; heat; high performance liquid chromatography; human; liver; lung; male; middle aged; myocardial perfusion imaging; procedures; randomization; scintiscanning; single photon emission computer tomography; thyroid gland; ultrasound; whole body imaging, Adult; Aged; Chromatography, High Pressure Liquid; Drug Compounding; Female; Gallbladder; Heart; Hot Temperature; Humans; Liver; Lung; Male; Middle Aged; Myocardial Perfusion Imaging; Radiopharmaceuticals; Random Allocation; Technetium Tc 99m Sestamibi; Thyroid Gland; Tomography, Emission-Computed, Single-Photon; Ultrasonic Waves; Water; Whole Body Imaging
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 10 Sep 2016 04:54
Last Modified: 10 Sep 2016 04:54
URI: http://eprints.goums.ac.ir/id/eprint/4691

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