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A forward to optimization of antivenom therapy: An in vivo study upon the effectiveness of the antivenom against early and delayed nephrotoxicity induced by the venom of the Iranian scorpion Hemiscorpius lepturus in rat

Pipelzadeh, M.H. and Jalali, A. and Dezfulian, A.R. and Khorasgani, Z.N. and Sarvestani, S. and Ghalambor, A.H. and Azarpanah, A. (2015) A forward to optimization of antivenom therapy: An in vivo study upon the effectiveness of the antivenom against early and delayed nephrotoxicity induced by the venom of the Iranian scorpion Hemiscorpius lepturus in rat. Toxicon, 100. pp. 13-19.

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Abstract

The aim of the present in vivo study was to identify the optimal effective dose, the most favorable time and the route of administration of the available polyvalent scorpion antivenom against the toxic effects induced by Hemiscorpius lepturus (H. lepturus) venom in rat. The end point for assessment included measurement of alanin-amino-peptidase (AAP) and N-acetyl-b-d-glucosaminidase (NAG), biochemical urine analysis and histopathological assessment. The results showed that a single subcutaneous 50 μg of the venom produced significant increase in the AAP and NAG enzyme activity, urinary biochemical parameters and induced histopathological structural abnormalities in the renal system. The optimal effective co-administered dose of the antivenom was 0.5 ml, which when administered 1 and 2 h of envenomation by intravenous (IV) and subcutaneous (SC) routes respectively produced significant protection against these toxic effects. Prudently, the significance of these findings need to be assessed in further clinical studies. © 2015 Elsevier Ltd.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: hemoglobin; microsomal aminopeptidase; n acetyl beta glucosaminidase; scorpion venom; scorpion venom antiserum; urobilinogen; acetylglucosaminidase; biological marker; peptide hydrolase; scorpion venom; venom antiserum, animal cell; animal experiment; animal model; animal tissue; Article; controlled study; diagnostic test accuracy study; disease marker; drug efficacy; early diagnosis; envenomation; enzyme activity; enzyme assay; glomerulus; Hemiscorpius lepturus; histopathology; in vivo study; kidney tubule; male; nephrotoxicity; nonhuman; poisonous scorpion; priority journal; protein localization; protein urine level; rat; rat model; renal protection; single drug dose; tissue distribution; toxicity testing; upregulation; urinalysis; animal; drug effects; hemoglobinuria; inbred rat strain; kidney; pathology; proteinuria; Scorpion Stings; time; urine, Lepturus; Rattus; Scorpiones, Acetylglucosaminidase; Animals; Antivenins; Biomarkers; Hemoglobinuria; Kidney; Male; Peptide Hydrolases; Proteinuria; Rats; Rats, Inbred Strains; Scorpion Stings; Scorpion Venoms; Time Factors
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 08 Sep 2016 18:24
Last Modified: 08 Sep 2016 18:24
URI: http://eprints.goums.ac.ir/id/eprint/4682

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