Golestan University of Medical Sciences Repository

Characteristics in childhood and adolescence associated with future multiple sclerosis risk in men: Cohort study

Gunnarsson, M. and Udumyan, R. and Bahmanyar, S. and Nilsagård, Y. and Montgomery, S. (2015) Characteristics in childhood and adolescence associated with future multiple sclerosis risk in men: Cohort study. European Journal of Neurology, 22 (7). pp. 1131-1137.

[img]
Preview
PDF - Published Version
Download (162kB) | Preview

Abstract

Background and purpose: Associations with multiple sclerosis (MS) of living conditions in childhood and characteristics in adolescence including physical fitness, cognitive function and psychological stress resilience were investigated. Methods: A cohort of male Swedish residents born 1952-1956 who were included in the Swedish Military Conscription Register was used to create a nested case-control study comprising 628 MS cases and 6187 controls matched on birth year, county of residence and vital status at time of diagnosis. Conscription examination records were linked with other national register data. Conditional logistic regression was used to evaluate associations with MS subsequent to the conscription examination. Results and conclusions: Men with MS were less likely to be from more crowded households in childhood (>two persons per room) with an adjusted odds ratio of 0.67 (95 confidence interval 0.51-0.86, P = 0.023). They had lower physical working capacity in adolescence with adjusted odds ratio of 0.94 (95 confidence interval 0.89-0.99, P = 0.026). Cognitive function and stress resilience scores displayed no significant differences between cases and controls. Parental occupation in childhood and body mass index in adolescence were not associated with future MS risk. The inverse association of MS risk with higher levels of household crowding may reflect environmental factors such as the pattern of exposure to microorganisms. Lower physical fitness in men at MS risk may indicate a protective effect of exercise or could be due to prodromal disease activity, although there was no association with cognitive function. Poor psychological stress resilience (and thus risk of chronic stress arousal) was not associated with MS. © 2015 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: adult; Article; body mass; case control study; chronic stress; cognition; cohort analysis; controlled study; coping behavior; disease activity; disease association; disease registry; environmental factor; exercise; fitness; groups by age; household; human; major clinical study; male; medical record review; mental stress; multiple sclerosis; occupation; priority journal; risk factor; Sweden; work capacity; adolescent; child; complication; coping behavior; demography; multiple sclerosis; physiology; preschool child; risk; statistics and numerical data; young adult, Adolescent; Adult; Case-Control Studies; Child; Child, Preschool; Cognition; Cohort Studies; Humans; Male; Multiple Sclerosis; Physical Fitness; Residence Characteristics; Resilience, Psychological; Risk; Stress, Psychological; Sweden; Young Adult
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 08 Sep 2016 17:58
Last Modified: 15 Jan 2017 06:13
URI: http://eprints.goums.ac.ir/id/eprint/4680

Actions (login required)

View Item View Item