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High cytotoxicity and apoptotic effects of natural bioactive benzofuran derivative on the MCF-7 breast cancer cell line

Soleimani, A. and Asadi, J. and Rostami-Charati, F. and Gharaei, R. (2015) High cytotoxicity and apoptotic effects of natural bioactive benzofuran derivative on the MCF-7 breast cancer cell line. Combinatorial Chemistry and High Throughput Screening, 18 (5). pp. 505-513.

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Abstract

This study was focused on evaluation of the cytotoxicity and apoptotic affects of benzofuran derivative on MCF-7 breast cancer cell line. This effective compound was isolated from the root of Petasites hybridus plant. For experiments, the MCF-7 cells were treated with several concentrations (0-500μM) of 1-(6-hydroxy-2-isopropenyl-1-benzofuran-5-yl)-1-ethanone 1 at different times. In this study, test of neutral red was also employed for cytotoxicity assay and quantity of P53, P21. Bax genes expression was analyzed using Real-Time PCR and ELISA techniques. Results show that compound 1 has cytotoxicity and apoptotic effects on Human breast cancer (Michigan Cancer Foundation-7) MCF-7 cells. © 2015 Bentham Science Publishers.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: 1 (6 hydroxy 2 isopropenyl 1 benzofuran 5 yl) 1 ethanone; benzofuran derivative; cytotoxic agent; neutral red; Petasites hybridus extract; protein Bax; protein p21; protein p53; unclassified drug; antineoplastic agent; benzofuran; benzofuran derivative; biological product, apoptosis; Article; cancer inhibition; cell survival; comparative study; concentration response; controlled study; cytotoxicity; cytotoxicity assay; drug effect; drug structure; enzyme linked immunosorbent assay; evaluation study; gene expression; human; human cell; in vitro study; MCF 7 cell line; nuclear magnetic resonance; Petasites; Petasites hybridus; plant root; priority journal; protein expression; real time polymerase chain reaction; upregulation; X ray; X ray crystallography; apoptosis; breast tumor; cell proliferation; chemical structure; chemistry; dose response; drug effects; drug screening; isolation and purification; MCF 7 cell line; pathology; structure activity relation, Petasites hybridus, Antineoplastic Agents, Phytogenic; Apoptosis; Benzofurans; Biological Products; Breast Neoplasms; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; MCF-7 Cells; Molecular Structure; Petasites; Plant Roots; Structure-Activity Relationship
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 08 Sep 2016 17:48
Last Modified: 08 Sep 2016 18:02
URI: http://eprints.goums.ac.ir/id/eprint/4679

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