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Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy

Bahrami, B. and Mohammadnia-Afrouzi, M. and Bakhshaei, P. and Yazdani, Y. and Ghalamfarsa, G. and Yousefi, M. and Sadreddini, S. and Jadidi-Niaragh, F. and Hojjat-Farsangi, M. (2015) Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy. Tumor Biology, 36 (8). pp. 5727-5742.

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Abstract

The selective and efficient drug delivery to tumor cells can remarkably improve different cancer therapeutic approaches. There are several nanoparticles (NPs) which can act as a potent drug carrier for cancer therapy. However, the specific drug delivery to cancer cells is an important issue which should be considered before designing new NPs for in vivo application. It has been shown that cancer cells over-express folate receptor (FR) in order to improve their growth. As normal cells express a significantly lower levels of FR compared to tumor cells, it seems that folate molecules can be used as potent targeting moieties in different nanocarrier-based therapeutic approaches. Moreover, there is evidence which implies folate-conjugated NPs can selectively deliver anti-tumor drugs into cancer cells both in vitro and in vivo. In this review, we will discuss about the efficiency of different folate-conjugated NPs in cancer therapy. © 2015, International Society of Oncology and BioMarkers (ISOBM).

Item Type: Article
Additional Information: cited By 9
Uncontrolled Keywords: albumin conjugate; alpha tocopherol succinate; berberine; camptothecin; chitosan nanoparticle; cisplatin; curcumin; dendrimer; doxorubicin; fluorouracil; folic acid conjugated nanoparticle; gamma glutamyl hydrolase; gemcitabine; gold nanoparticle; idarubicin; magnetic nanoparticle; melphalan; mercaptopurine; mesoporous silica nanoparticle; mitoxantrone; nanoparticle; paclitaxel; pemetrexed; plasmid DNA; platinum complex; polymer; silica nanoparticle; tamoxifen; unclassified drug; unindexed drug; vinblastine sulfate; drug carrier; folate receptor; folic acid; micelle; nanoparticle, antineoplastic activity; apoptosis; breast cancer; cancer inhibition; cancer therapy; cytotoxicity; drug delivery system; drug efficacy; drug potency; gastric cancer cell line; HeLa cell line; HepG2 cell line; human; liver cancer cell line; malignant neoplastic disease; micelle; molecularly targeted therapy; nonhuman; ovarian cancer cell line; pancreatic cancer cell line; pharynx cancer; phase 3 clinical trial (topic); priority journal; prostate cancer cell line; Review; biosynthesis; chemistry; gene expression regulation; genetics; Neoplasms; pathology, Drug Carriers; Folate Receptors, GPI-Anchored; Folic Acid; Gene Expression Regulation, Neoplastic; Humans; Micelles; Molecular Targeted Therapy; Nanoparticles; Neoplasms
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 08 Sep 2016 17:47
Last Modified: 15 Jan 2017 18:18
URI: http://eprints.goums.ac.ir/id/eprint/4678

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