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Myeloid-derived suppressor cells in B cell malignancies

Yazdani, Y. and Mohammadnia-Afrouzi, M. and Yousefi, M. and Anvari, E. and Ghalamfarsa, G. and Hasannia, H. and Sadreddini, S. and Jadidi-Niaragh, F. (2015) Myeloid-derived suppressor cells in B cell malignancies. Tumor Biology, 36 (10). pp. 7339-7353.

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Abstract

Tumor cells use several mechanisms such as soluble immune modulators or suppressive immune cells to evade from anti-tumor responses. Immunomodulatory cytokines, such as transforming growth factor-β, interleukin (IL)-10, and IL-35, soluble factors, such as adenosine, immunosuppressive cells, such as regulatory T cells, NKT cells and myeloid-derived suppressor cells (MDSCs), are the main orchestra leaders involved in immune suppression in cancer by which tumor cells can freely expand without immune cell-mediated interference. Among them, MDSCs have attracted much attention as they represent a heterogenous population derived from myeloid progenitors that are expanded in tumor condition and can also shift toward other myeloid cells, such as macrophages and dendritic cells, after tumor clearing. MDSCs exert their immunosuppressive effects through various immune and non-immune mechanisms which make them as potent tumor-promoting cells. Although, there are several studies regarding the immunobiology of MDSCs in different solid tumors, little is known about the precise characteristics of these cells in hematological malignancies, particularly B cell malignancies. In this review, we tried to clarify the precise role of MDSCs in B cell-derived malignancies. © 2015, International Society of Oncology and BioMarkers (ISOBM).

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: colony stimulating factor 1; granulocyte colony stimulating factor; granulocyte macrophage colony stimulating factor; immunoglobulin enhancer binding protein; Janus kinase; STAT1 protein, B cell leukemia; B cell lymphoma; cell expansion; cell function; hematologic malignancy; human; molecular pathology; multiple myeloma; myeloid derived suppressor cell; nonhuman; priority journal; protein expression; Review; signal transduction; suppressor cell; animal; B lymphocyte; bone marrow cell; cellular immunity; immunology; neoplasm; pathology, Animals; B-Lymphocytes; Humans; Immunity, Cellular; Myeloid Cells; Neoplasms
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 08 Sep 2016 17:11
Last Modified: 16 Jan 2017 07:07
URI: http://eprints.goums.ac.ir/id/eprint/4664

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