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Tumor dose enhancement by nanoparticles during high dose rate 192 Ir brachytherapy

Zabihzadeh, M. and Arefian, S. (2015) Tumor dose enhancement by nanoparticles during high dose rate 192 Ir brachytherapy. Journal of Cancer Research and Therapeutics, 11 (4). pp. 752-759.

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Abstract

Aims and Objectives: The present study aims to evaluate and compare the dose enhancement factor (DEF) of tumor injected with different nanoparticles (NPs) around high dose rate (HDR) 192 Ir brachytherapy source. Materials and Methods: Monte Carlo calculations were performed with MCNPX code to determine the DEF caused by in tumor injected with 79 Au, 64 Gd, 26 Fe, and 22 Ti NPs during HDR 192 Ir brachytherapy. The uniform and non-uniform distribution of NPs within tumor was modeled with simple NPs-water mixture, and realistic nano-scale-lattice model. Furthermore, a margin of 79 Au and 64 Gd NPs was implemented around the tumor volume. Results: The increased dose caused by uniformly distributed 79 Au and 64 Gd NPs with 7, 18, and 30 mgr/gr concentrations was 4.7, 11.8, 19.4, and 3.3, 8.3, and 18.6, respectively. For non-uniform distribution, it was 0.4, 1.2, 1.9, and 0.2, 0.7, and 1.2, respectively. Increased tumor dose due to 26 Fe and 22 Ti was not significant. The peripheral-healthy tissue dose as margin with 2, 5, and 8.5 mgr/gr of 79 Au and 64 Gd increased by 1.3, 3.6, 6.5, and 1.1, 2.5, and 4.2, respectively. Increase the radial depth of tumor (from 1.5 to 5 cm) increase DEF (up to 22.3). The nano-lattice model underestimated the DEF up to 4 and 3.6 for 79Au and 64 Gd NPs, respectively. Conclusion: Injecting of high-Z gold NPs into tumor increases the absorbed dose of tumor irradiated with 192 Ir HDR brachytherapy source. Size, geometry, concentration, and distribution model of NPs and tumor depth are crucial factors to accurately estimate the DEF. © 2015 Journal of Cancer Research and Therapeutics | Published by Wolters Kluwer - Medknow.

Item Type: Article
Additional Information: cited By 0
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 08 Sep 2016 10:04
Last Modified: 08 Sep 2016 10:04
URI: http://eprints.goums.ac.ir/id/eprint/4662

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