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Comparison of the eight-hour with the 22-hour infusion of 5-fluorouracil, in the folfox chemotherapy of colon cancer: A retrospective study

Shahbazian, H. and Razmjoo, S. and Arvandi, S. and Hosseini, S.M. and Hoseinzadeh, M. and Deilamani, A.A. and Mohammadian, F. (2016) Comparison of the eight-hour with the 22-hour infusion of 5-fluorouracil, in the folfox chemotherapy of colon cancer: A retrospective study. Jundishapur Journal of Natural Pharmaceutical Products, 11 (2).

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Abstract

Background: The optimal protocol for administration of 5-fluorouracil (5-FU) in chemotherapy of colorectal cancer is unknown. Objectives:Wecompared treatment outcomes of short-time infusion of 5-FU (8-hour infusion) with 22-hour infusion, in chemotherapy management of colorectal cancer. Patients and Methods: A retrospective study was conducted on colon cancer patients, who have been treated for at least 24 weeks with the FOLFOX regimen (5-FU, leucovorin, and oxaliplatin). Patients who had received infusion of 5-FU, either over 8 hours (5-FU 8h) or over 22 hours (5-FU 22h) were selected. The study endpoints were 3 and 5 years disease free survival and overall survival. Results: A total of 58 patients, in the 5-FU 8h, and 50 patients, in the 5-FU 22h groups, were studied. Based on the intention-to-treat analysis, there was a lower overall mortality (44 vs. 22.4, P = 0.023) and lower overall relapse (46 vs. 18.9, P = 0.004), as well as a higher 3 years disease free survival (81 vs. 58, P = 0.011) in the 5-FU 8h, compared with 5-FU 22h group. The Log Rank test showed a difference between the two groups, for disease free survival (P = 0.008), as well as overall survival (P = 0.014), confirmed by Cox Regression analysis: hazard ratio 95% CI = 0.365 0.160 to 0.833 and 0.286 0.100 to 0.817, respectively. Conclusions: We found better outcomes for the colon cancer patients, who had received infusion of 5-FU 8h, compared with 5-FU 22h, in the FOLFOX chemotherapy. These findings should be tested in prospective clinical trials. © 2016, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences.

Item Type: Article
Additional Information: cited By 0
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 07 Sep 2016 08:42
Last Modified: 07 Sep 2016 08:42
URI: http://eprints.goums.ac.ir/id/eprint/4627

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