Golestan University of Medical Sciences Repository

Tumor necrosis factor alpha -308 G/A single nucleotide polymorphism and susceptibility to hepatocellular carcinoma via hepatitis B infection

Azar, S.S. and Mansoori, M. and Attar, M. and Shahbazi, M. (2016) Tumor necrosis factor alpha -308 G/A single nucleotide polymorphism and susceptibility to hepatocellular carcinoma via hepatitis B infection. Asian Pacific Journal of Cancer Prevention, 17 (7). pp. 3381-3384.

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Abstract

Background: Hepatitis B virus (HBV) is a key factor for hepatocellular carcinoma (HCC). About 350 million people are affected by chronic infection which is related to the rapid development of liver diseases as well as hepatitis, cirrhosis and hepatocellular carcinoma. Expression of tumor necrosis factor alpha (TNF-α) in the liver demonstrates a major genetic polymorphism which is involved in resistance or susceptibility to chronic HBV infection. Materials and Methods: In this study, two populations were studied by the sequence specific primer-polymerase chain reaction (SSP-PCR) method: HBV cases (n=409), who were HBS-Ag+, and healthy controls (n=483). Results: The results shown that the frequency of TNF-α-308 G/G genotype in healthy controls (47.2%) was significantly higher than in HBV infected patients (28%) (CI = 1.29-2.61, OR = 1.83, P = 0.0004). Also TNF-α -308 A/A and A/G genotype frequencies in the healthy controls were 4.6% and 48.2% and in patient group were 19.5% and 52.5% (CI = 2.23-7.12, p: 0.0001, OR: 3.94) respectively. Conclusions: We found that among Iranian people TNF-α -308A allele not only has the highest genotype frequency but also it has the highest frequency in the world population. In addition, TNF-α-308 G/G polymorphism was associated with HBV resistance, whereas TNF-α-308A (A/A or A/G) polymorphism appeared to associated with chronic HBV infection. These data suggested that among the Iranian population, the -308 G/G polymorphism of TNF-α gene promoter region has the potential to influence the susceptibility to HBV infection and it may be responsible for viral antigen clearance.

Item Type: Article
Additional Information: cited By 0
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 08 Sep 2016 05:29
Last Modified: 08 Sep 2016 05:29
URI: http://eprints.goums.ac.ir/id/eprint/4612

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