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Evaluation of administration of oral N-acetylcysteine to reduce oxidative stress in chronic hemodialysis patients: A double-blind, randomized, controlled clinical trial

Shahbazian, H. and Shayanpour, S. and Ghorbani, A. (2016) Evaluation of administration of oral N-acetylcysteine to reduce oxidative stress in chronic hemodialysis patients: A double-blind, randomized, controlled clinical trial. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 27 (1). pp. 88-93.

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Abstract

This study was designed to assess the efficacy of N-acetylcysteine (NAC) on the reduction of oxidative stress in chronic hemodialysis (HD) patients through measurement of total serum anti-oxidant capacity. In this randomized, double-blind, controlled clinical trial, the efficacy and safety of NAC in reduction of oxidative stress was evaluated in 40 chronic HD patients. The study was conducted at the HD Department of the Golestan Hospital, Ahvaz, Iran. Data were analyzed using SPSS version 19. Paired samples test showed that the mean score of the serum level of total anti-oxidant capacity (TAC) increased from 26.39±17.03 to 33.26±18.8 (Pvalue=0.01) and from 24.02±16.47 to 25.38±17.04 (P=0.1) in the NAC and placebo groups, respectively. Difference in the mean TAC changes between groups was statistically significant (P=0.042). In our study, NAC administration could reduce oxidative stress in chronic HD patients. No major side-effects were observed.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: acetylcysteine; scavenger, adult; controlled study; dose response; double blind procedure; drug effects; female; human; Kidney Failure, Chronic; male; metabolism; oxidative stress; prospective study; randomized controlled trial; renal replacement therapy; time; treatment outcome, Acetylcysteine; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Free Radical Scavengers; Humans; Kidney Failure, Chronic; Male; Oxidative Stress; Prospective Studies; Renal Dialysis; Time Factors; Treatment Outcome
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 08 Sep 2016 05:16
Last Modified: 08 Sep 2016 05:16
URI: http://eprints.goums.ac.ir/id/eprint/4603

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