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Crocin loaded nano-emulsions: Factors affecting emulsion properties in spontaneous emulsification

Mehrnia, M.-A. and Jafari, S.-M. and Makhmal-Zadeh, B.S. and Maghsoudlou, Y. (2016) Crocin loaded nano-emulsions: Factors affecting emulsion properties in spontaneous emulsification. International Journal of Biological Macromolecules, 84. pp. 261-267.

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Abstract

Spontaneous emulsification may be used for encapsulating bioactive compounds in food and pharmaceutical industry. It has several advantages over high energy and other low energy methods including, protecting sensitive compounds against severe conditions of high energy method and its ability to minimize surfactant, removal of cosurfactant and thermal stability compared with other low energy methods. In this study, we examined possibility of encapsulating highly soluble crocin in W/O micro-emulsions using spontaneous method which further could be used for making double emulsions. Nonionic surfactants of Span 80 and polyglycerol polyricinoleate (PGPR) were used for making micro-emulsions that showed the high potential of PGPR for spontaneous method. Surfactant to water ratio (SWR) was evaluated to find the highest amount of aqueous phase which can be dispersed in organic phase. Droplet size decreased by increasing SWR toward the SWR = 100 which had the smallest droplet size and then increased at higher levels of surfactant. By increasing SWR, shear viscosity increased which showed the high effect of PGPR on rheological properties. This study shows in addition to W/O micro-emulsions, spontaneous method could be used for preparing stable O/W micro-emulsions. © 2015 Elsevier B.V.

Item Type: Article
Additional Information: cited By 4
Uncontrolled Keywords: cosurfactant; crocin; nonionic surfactant; polyglycerol polyricinoleate; sorbitan oleate; surfactant; unclassified drug; water oil cream, Article; controlled study; drug industry; emulsion; encapsulation; energy; flow kinetics; food industry; microemulsion; nanoemulsion; thermostability; viscosity
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 07 Sep 2016 08:47
Last Modified: 13 Sep 2016 07:53
URI: http://eprints.goums.ac.ir/id/eprint/4580

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