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Regional vulnerability of the hippocampus to repeated motor activity deprivation

Faraji, J. and Soltanpour, N. and Moeeini, R. and Hosseini, S.A. and Pakdel, S. and Moharrerie, A. and Arjang, K. and Soltanpour, N. and Metz, G.A.S. (2016) Regional vulnerability of the hippocampus to repeated motor activity deprivation. Behavioural Brain Research, 301. pp. 178-189. ISSN 18727549

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Spontaneous vertical and horizontal exploratory movements are integral components of rodent behavior. Little is known, however, about the structural and functional consequences of restricted spontaneous exploration. Here, we report two experiments to probe whether restriction in vertical activity (rearing) in rats could induce neuro-hormonal and behavioral disturbances. Rearing movements in rats were deprived for 3 h/day for 30 consecutive days by placing the animal into a circular tunnel task. Rats temporarily deprived of rearing behavior showed elevated plasma corticosterone levels but no detectable psychological distress and/or anxiety-related behavior within an elevated plus maze. However, rats emitted a greater number of 22-kHz ultrasonic vocalizations and spent significantly more time vocalizing than controls when deprived of their rearing behavior. Despite intact spatial performance within wet- and dry-land spatial tasks, rearing-deprived rats also exhibited a significant alteration in search strategies within both spatial tasks along with reduced volume and neuron number in the hippocampal subregion CA2. These data suggest a new approach to test the importance of free exploratory behavior in endocrine and structural manifestations. The results support a central role of the CA2 in spontaneous exploratory behavior and vulnerability to psychological stress. © 2015 Elsevier B.V.

Item Type: Article
Additional Information: cited By 0
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 07 Sep 2016 10:23
Last Modified: 07 May 2018 08:13
URI: http://eprints.goums.ac.ir/id/eprint/4567

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