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Optimization of folic acid nano-emulsification and encapsulation by maltodextrin-whey protein double emulsions

Assadpour, E. and Maghsoudlou, Y. and Jafari, S.-M. and Ghorbani, M. and Aalami, M. (2016) Optimization of folic acid nano-emulsification and encapsulation by maltodextrin-whey protein double emulsions. International Journal of Biological Macromolecules, 86. pp. 197-207. ISSN 18790003

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Due to susceptibility of folic acid like many other vitamins to environmental and processing conditions, it is necessary to protect it by highly efficient methods such as micro/nano-encapsulation. Our aim was to prepare and optimize real water in oil nano-emulsions containing folic acid by a low energy (spontaneous) emulsification technique so that the final product could be encapsulated within maltodextrin-whey protein double emulsions. A non ionic surfactant (Span 80) was used for making nano-emulsions at three dispersed phase/surfactant ratios of 0.2, 0.6, and 1.0. Folic acid content was 1.0, 2.0, and 3.0 mg/mL of dispersed phase by a volume fraction of 5.0, 8.5, and 12. The final optimum nano-emulsion formulation with 12 dispersed phase, a water to surfactant ratio of 0.9 and folic acid content of 3 mg/mL in dispersed phase was encapsulated within maltodextrin-whey protein double emulsions. It was found that the emulsification time for preparing nano-emulsions was between 4 to 16 h based on formulation variables. Droplet size decreased at higher surfactant contents and final nano-emulsions had a droplet size. < 100 nm. Shear viscosity was higher for those formulations containing more surfactant. Our results revealed that spontaneous method could be used successfully for preparing stable W/O nano-emulsions containing folic acid. © 2016 Elsevier B.V.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: canola oil; folic acid; maltodextrin; nonionic surfactant; whey protein, Article; chemical parameters; controlled study; crystallization; dispersed phase surfactant ratio; droplet size; drug dosage form comparison; drug structure; emulsification time; emulsion; nanoemulsification; nanoencapsulation; photon correlation spectroscopy; precipitation; process optimization; reproducibility; response surface method; sedimentation; shear viscosity; surface area; time; validation process; viscosity; water to surfactant ratio
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 07 Sep 2016 10:11
Last Modified: 07 May 2018 07:35
URI: http://eprints.goums.ac.ir/id/eprint/4555

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