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The effects of endosulfan on P450 1A gene expression, antioxidant enzymes activity and histopathological alterations in liver of Persian sturgeon (Acipenser persicus Borodin, 1987)

Safari, R. and Khalili, M. and Reza Imanpour, M. and Pourkazemi, M. (2016) The effects of endosulfan on P450 1A gene expression, antioxidant enzymes activity and histopathological alterations in liver of Persian sturgeon (Acipenser persicus Borodin, 1987). Journal of Applied Ichthyology, 32 (4). pp. 636-642.

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Abstract

The effects of 14 days exposure to sublethal concentrations of endosulfan (10 and 40 μg L−1) were investigated in mRNA- P450 1A expression, antioxidant enzymes (SOD and CAT) activity and histopathological alterations of Persian sturgeon (Acipenser persicus) fingerlings with weights of 3–5 g. The results illustrated that the relative mRNA- P450 1A expression level significantly increased (P < 0.05) compared to the control group. Highest significant increase (P < 0.05) was observed on the first day, then decreased towards day 14 of exposure. The SOD and CAT activity showed a significant increase in fish exposed to different concentrations up to day 7, then activity decreased on day 14 in fish of all treated groups. Although signs of tissue lesions were observed on day 4, they increased from day 7 and reached the highest level on day 14. The magnitude of all changed studied parameters (gene expression, enzymes and histopathological) follows a concentration-dependent manner. © 2016 Blackwell Verlag GmbH

Item Type: Article
Additional Information: cited By 0
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 07 Sep 2016 09:20
Last Modified: 26 Sep 2016 07:28
URI: http://eprints.goums.ac.ir/id/eprint/4529

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