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Assessment of babA2 and hsp genotype frequency in Helicobacter pylori specimens isolated from digestive disorders patients

Heidari, K. and Azarhoush, R. and Forghanifar, M. and Azarhoush, R. (2015) Assessment of babA2 and hsp genotype frequency in Helicobacter pylori specimens isolated from digestive disorders patients. / Journal of Gorgan University of Medical Sciences, 16 (4).

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Abstract

Abstract Background and Objective: Helicobacter pylori is the main gastric pathogen in human. BabA2 and Hsp genotypes are essential for enormous clinical outcomes in gastreodeoneal and dyspepsia. This study was done to determine the assessment of babA2 and hsp genotype frequency in Helicobacter pylori specimens isolated from digestive disorders patients. Method: This descriptive-analytic study was carried out on 80 digestive disorders patients in 5 th hospital, Gorgan, northern Iran. Stomach specimen biopsy was taken by a gastroenterologist. Urease test, histopathologic assessment and DNA extraction were performed. The frequency of babA2 and hsp genotypes was determined using poly merase chain reaction. Results: In 80 affected patients with H.pylori, 36, 18 and 26 patients were found to suffer from gastritis, stomach cancer and stomach ulcer, respectively. 51 specimens (63%) were positive babA2 genotype. 49 specimens (61%) were positive hsp genotype. No significant relationship was found between babA2 and hsp geno types with stomach diseases. Conclusion: In spite of positive babA2 and hsp genotype in isolated Helicobacter pylori speicments from digestive disorders patients, this finding was not correlated with type of digestive disorders. Keywords: Helicobacter pylori, babA2 gene, Hsp gene, Gastric disease

Item Type: Article
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 05 May 2015 09:16
Last Modified: 08 Jun 2015 04:27
URI: http://eprints.goums.ac.ir/id/eprint/4160

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