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Role of genetic variation tumour necrosis factor alpha-380 in Iranian multiple sclerosis

Ebadi, H. and Shahbazi, M. (2008) Role of genetic variation tumour necrosis factor alpha-380 in Iranian multiple sclerosis. JOURNAL OF NEUROLOGY, 255 (2). pp. 206-207.

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Introduction: Multiple sclerosis (MS) is a polygenic inflammatory autoimmune disorder associated with progressive demylination in central nervous system. Tumor necrosis factor-alpha (TNF-α), a proinflammatory cytokine, is believed to play an important role in MS pathogenesis. polymorphism in the (TNF-α -308 G/A), has been reported to influence levels of TNF-a production.The objective of this study was to determine whether sequence variation in the TNF-α gene at position-308 is associated with Iranian MS patients and healthy individual controls. Material and methods: Genomic DNA samples were prepared from whole blood of 126 MS Patients and 138 control subjects. Patients were divided into two groups according to their expanded disability status scale (EDSS) with mild to moderate or severe disease. The genotypes were determined by SSP-PCR. Student t test and X2 analyses were applied to determine differences between groups. Result: Frequencies of genotypes and alleles were significantly different between MS and Control subjects (X2 = 8.92,p = 0.02; OR = 1.56; 95 % CI = 1.05–2.33). Whereas, there were no statistical differences between early and late onset of MS. Moreover, there were no statistically significant differences between types of MS.Nevertheless, we have not found any statistical significant differences between affected patients in comparison with mild to moderate MS patients. Discussion: Our results have shown that TNF-α 308 (G/A) polymorphism is strongly associated with development of multiple sclerosis in this population.It seems that high production of TNF-α predicts susceptibility to MS in Iranian population. Likewise, it may be a considerable genetic predisposition for MS disease.

Item Type: Article
Additional Information: 18th Meeting of the European-Neurological-Society, Nice, FRANCE, JUN 07-11, 2008
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 27 Apr 2015 10:45
Last Modified: 19 Jun 2017 09:15
URI: http://eprints.goums.ac.ir/id/eprint/4096

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