Golestan University of Medical Sciences Repository

The role of interleukin-2 in the development and course of multiple sclerosis is influenced fly HLA-DRB alleles in the Iranian population

Shahbazi, M. and Ebadi, H. and Roshandel, D. and Mohammadhosseini, M. (2008) The role of interleukin-2 in the development and course of multiple sclerosis is influenced fly HLA-DRB alleles in the Iranian population. MULTIPLE SCLEROSIS, 14. S199-S200.

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Abstract

Background: Recent genome-wide association studies have shown that cytokine gene polymorphisms may play an important role in the pathogenesis of multiple sclerosis (MS). Several studies have revealed that alleles at or near the class II loci HLA-DRB1 and HLA-DQB1 contribute significantly to genetic risk. In particular, DRB1*15 is a significant predisposing factor for MS development and may influence the role of other genes. Objective: To study the impact of interleukin (IL)-2/-330 single nucleotide polymorphism and its combination with HLA-DRB alleles. Methods: We used sequence-specific, primerpolymerase chain reaction to profile the genetic polymorphism of 130 MS patients and 139 healthy controls from the Iranian population. HLA-DRB alleles were determined by standard manufacture’s protocol in all cases. Data were analyzed by STATA software with twosided Fisher’s exact test. P values less than 0.05 were assumed to be significant. To identify the influence of these genotypes on the course of the disease, patients were divided into subgroups according to their age at onset, progression index (Expanded Disability Status Scale (EDSS)/years) and type of MS. Results: We observed a significant increase of the T allele and T/T genotype in the -330 position of the IL-2 gene (43 and 169 vs. 29 and 156, respectively in patients and controls, P <0.05). However, this polymorphism did not affect onset, type or severity of disease. Besides the HLA-DRB alleles, the T/G genotype was less frequent among HLA-DRB1*01, DRB1*16, DRB1*07, DRB1*11, DRB1*13, DRB1*14, DRB3*01, DRB4*01 and DRB5*01 positive patients (P <0.05). In addition, the DRB1*0103 allele besides the T/T genotype was significantly associated with MS (15 patients vs. 0 controls, P <0.0003). Furthermore, the T/G genotype was associated with early onset in DRB1*10 positive patients and with non-relapsingremitting disease in DRB1*15 positive and DRB5*01 positive patients. Conclusions: Our results suggest that IL-2 is a key cytokine in the pathogenesis of MS, particular when associated with HLA-DRB alleles in the Iranian population.

Item Type: Article
Additional Information: 13th Annual Meeting of the Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/24th Congress of the European-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/5th Congress of the Latin-Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis, Montreal, CANADA, SEP 17-20, 2008
Subjects: موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 27 Apr 2015 10:42
Last Modified: 25 Jun 2017 04:26
URI: http://eprints.goums.ac.ir/id/eprint/4087

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