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The assessment of relation between presence of side effects resulting from dipyridamole injection during myocardial perfusion imaging with hemodynamic changes, electrocardiographic and scan findings

Javadi, H. and Shariati, M. and Jalallat, S. and Mogharrabi, M. and Asli, I.Neshandar and Bahafar, N. and Shiroodi, M. and Assadi, M. (2009) The assessment of relation between presence of side effects resulting from dipyridamole injection during myocardial perfusion imaging with hemodynamic changes, electrocardiographic and scan findings. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 36 (2). S313.

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Abstract

Aim: Evaluation the prevalence of side effects due to dipyridamole injection, during myocardial perfusion imaging, and their correlation with hemodynamic changes and scan findings . Materials & Methods: Before starting the stress phase myocardial perfusion imaging , electrocardiogram, blood pressure and heart rate of all the patients were registered and then, dilute dipyridamole amounting to 0.568 mg/kg in 10 ml of normal saline was infused within 4 minutes . Within the period of infusion, the patient's electrocardiogram, HR, SBP, DBP, and any complaint of them was recorded. Results: In this study, we examined 590 patients (Mean ± SD; 57 ± 11 year old), who performed myocardial perfusion scan with intravenous dipyridamole in stress phase. In order to assessment the relation between side effects, hemodynamic response to dipyridamole infusion, myocardial perfusion imaging , and electrocardiographic findings , we evaluated resting and post‐infusion changes of HR, SBP, DBP. There is no significant difference in mean ± SD of resting HR (82 ± 12 beat/minute, vs 82 ± 10 beat/minute; p > 0.05), resting DBP (79 ± 9 mmHg ,vs 79 ± 10 mmHg; p> 0.05), and stress SBP (132 ± 20 mmHg vs 131 ± 23 mmHg ; p > 0.05) in patients without and with symptoms. However, significant difference in mean ± SD of post‐infusion HR (88 ± 13 beat/minute, vs 92 ± 10 beat/minute ; p = 0.016), rest SBP (139 ± 20 mmHg, vs 133 ± 23 mmHg ; p = 0.024), stress DBP (76 ± 9 mmHg ,vs 72 ± 10 mmHg ; p = 0.003), were noted in patients with and without symptoms. Conclusion: Our data demonstrated that most of side effects are self limiting and occur in patients with basic abnormalities in their ECG and scan findings.

Item Type: Article
Subjects: موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 27 Apr 2015 10:34
Last Modified: 20 Jun 2017 07:06
URI: http://eprints.goums.ac.ir/id/eprint/4054

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