Golestan University of Medical Sciences Repository

Role of IL-2 in development and course of multiple sclerosis is influenced by HLA-DRB alleles in an Iranian population

Shahbazi, M. and Ebadi, H. and Fathi, D. and Mahammadhoseeni, M. and Rashidbaghan, A. and Roshandel, D. (2009) Role of IL-2 in development and course of multiple sclerosis is influenced by HLA-DRB alleles in an Iranian population. EUROPEAN JOURNAL OF NEUROLOGY, 16. p. 271.

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Abstract

Background and aims: Recent genome wide association studies have shown that cytokine gene polymorphisms might play an important role in the pathogenesis of multiple sclerosis (MS). We have studied the impact of IL-2/-330 single nucleotide polymorphism (SNP) and its combination with HLA-DRB alleles in Iranian population. Materials and methods: We used sequence specific primer-polymerase chain reaction (SSP-PCR) to profile the genetic polymorphism of 241 MS patients and 264 healthy controls from Iranian population. HLA-DRB alleles were determined by standard manufacture protocol for all cases. The 2-sided Fisher’s exact test was applied to calculate the significance of differences of allele and genotype frequencies between two groups and P-values less than 0.05 were assumed to be significant. Results:Analysis of IL-2 promoter polymorphisms showed significant differences between controls and patients. We observed a significant increase of T allele and T/T genotype in the -330 position of IL-2 gene. However, this polymorphism didn’t affect onset, type or severity of disease. Beside HLA-DRB alleles, T/G genotype was less frequent among HLA-DRB1*01, DRB1*16, DRB1*07, DRB1*11, DRB1*13, DRB1*14, DRB3*01, DRB4*01 and DRB5*01 positive patients (p<0.05). In addition, DRB1*0103 allele besides T/T genotype was significantly associated with MS (15 patients vs. 0 controls, p<0.0003). Furthermore, T/G genotype was associated with early onset in DRB1*10 positive patients and with non-relapsing remitting disease in DRB1*15 positive and DRB5*01 positive patients. Conclusion: Our results suggest that IL-2 is a key cytokine in the pathogenesis of MS in the Iranian population especially in corporation with HLA-DRB alleles.

Item Type: Article
Additional Information: 13th Congress of the European-Federation-of-Neurological-Societies, Florence, ITALY, SEP 12-15, 2009
Subjects: موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 27 Apr 2015 10:33
Last Modified: 25 Jun 2017 03:51
URI: http://eprints.goums.ac.ir/id/eprint/4049

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