Golestan University of Medical Sciences Repository

Anti-spasmodic properties of Matricaria recutita L. cultivated in Golestan province of Iran: potential role of nitrergic and cholinergic pathways

Khori, V. and Hossini, F. and Biat, H. and Changizi, S. and Mazandarani, M. and Sifi, A. (2010) Anti-spasmodic properties of Matricaria recutita L. cultivated in Golestan province of Iran: potential role of nitrergic and cholinergic pathways. PLANTA MEDICA, 76 (12). p. 1360.

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Abstract

Introduction: Previous studies revealed anti-inflammatory and anti-spasmodic effects of Matricaria recutita. The objective of present study is to determine: 1) the effect of spray dried total extract of M. recutita collected in Golestan province of Iran on contractile phase of isolated jejunum of rabbit 2) the role of Cholinergic and Nitregic systems on anti-spasmodic effects of M. recutita. Material &Methods: In first groups (N=6), the effects of increasing concentrations of plant extract on the contractile responses of jejunum of rabbits induced by cumulative addition of extracellular calcium and high K+ were studied. The role of the nitrergic and cholinergic systems was assessed in the presence of various concentrations of M. recutita (0.003–0.013mg/ml) and cholinerhic and nitrergic modulators at the second and third groups (N=12). Results: Significant concentration-dependet inhibitory effects of M. recutita on contraction of smooth muscle caused by cumulative concentrations of calcium (0.03–3 mM) and to 50 mM Kcl was observed. Pretreatments with L-Name (100µm) and atropine (3µm) abrogated effectively the spasmolytic effect of M. recutita. Although, the M. recutita effect was significantly reduced in preparations pretreated with L-Argening (100mM), a precursor of Nitric Oxide production. Interestingly, contractile response of smooth muscle to Ach was completely reverted by M. recutita Conclusion:Our results indicate that the anti-spasmodic effects of Matricaria recutita arise from its direct inhibitory effects on Ca2+ channels. however, modulation of cholinergic and nitregic pathway could be involved. These observations suggest that Matricaria recutita inhibit contractile elements of peristalsis by facilitating inhibitory role of nitrergic pathway.

Item Type: Article
Additional Information: 7th Tannin Conference/58th International Congress and Annual Meeting of the Society-for-Medical-Plant-and-Natural-Product-Research, Berlin, GERMANY, AUG 29-SEP 02, 2010
Subjects: موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 27 Apr 2015 04:46
Last Modified: 20 Jun 2017 08:50
URI: http://eprints.goums.ac.ir/id/eprint/4008

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