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Lack of electrophysiological remodeling of atrioventricular-node in isolated perfused cirrhotic rat during simulated atrial fibrilation

Moheimani, H.R. and Khori, V. and Dehpour, A.R. (2010) Lack of electrophysiological remodeling of atrioventricular-node in isolated perfused cirrhotic rat during simulated atrial fibrilation. EUROPEAN JOURNAL OF MEDICAL RESEARCH, 15 (1). p. 27.

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Abstract

Objective: The present study is design to evaluate the protective electrophsiological role of Atrioventricular- Node (AV-Node) during laboratory simulated Atrial fibrillation in common bile-duct ligated (BDL) rats. Material and Methods : We compared the electrophysiological effects of cirrhosis in 18 isolated perfused rat heart randomly divided in 3 groups:1)sham 2)basic and rate dependent and 3)AF. Cirrhosis was induced by BDL for 6 weeks in rats. We used extracellular filed potential recording from upper atrium and right ventricular. The conduction time, refractoriness and frequency-dependent (Recovery, Facilitation and Fatigue) properties of AVNode were characterized by specific stimulation protocols. Experimental AF was simulated by high-rate atrial pacing with random coupling intervals (range 75/125 ms). All data shown as Mean ± SE. Results : Slow pathway conduction time and nbsp; and facilitation interval was prolonged in cirrhotic rats (78.8 ± 3.3 to 95.8 ± 4.2 ms in sham and cirrhotic rats, respectively). Nodal protective function during AF(R-R interval, concealed beats, ventricular refractoriness and zone of concealment) weren't affected by cirrhosis. Conclusion: Despite slow pathway conduction prolongation in cirrhotic rats, protective behavior of av-node didn't change after induction of cirrhosis.

Item Type: Article
Subjects: موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 27 Apr 2015 10:09
Last Modified: 23 Jun 2017 19:38
URI: http://eprints.goums.ac.ir/id/eprint/3991

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