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A novel scintigraphic agent, 99m Tc -UBI 29-41, to monitor antibiotic therapy in patients with orthopedic infection

Nazari, B. and Azizmohammadi, Z. and Rajaei, M. and Karami, M. and Javadi, H. and Assadi, M. and Asli, I.N. (2011) A novel scintigraphic agent, 99m Tc -UBI 29-41, to monitor antibiotic therapy in patients with orthopedic infection. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 38 (2). S410.

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Abstract

Aim: Ubiquicidin (UBI) 29-41 is a cationic synthetic antimicrobial peptide fragment that binds preferentially with anionic microbial cell membranes at the site of infection. The current study evaluated the potential ability of 99m Tc-UBI 29-41 to assess response to antibiotic therapy in orthopedic infection.Matherials and methods: A total of 12 patients, 10 male and 2 female (mean age 41.6y; range 23- 75y), with suspected orthopedic infection (bone, soft tissue, or prosthesis) and positive UBI scan for infection were included in the study. One day after the 99m Tc-UBI scan, a bone scan was performed as well. After the first scan series, 9 of the 12 patients underwent appropriate treatment including empirical antibiotics; 3 patients refused treatment. After a 10-14 day interval all patients were divided into two groups: a) responder to therapy and 2) non-responder/non-treated. In all 12 patients, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were measured; and in most of them, wound cultures were carried out before and after the 10-14 day interval. Then, 3 of the 4 patients in the non-responder/non-treated group underwent antibiotic therapy and were evaluated again after 10-14 days. One of these patients responded to recent therapy and 2 patients did not. Thus, 15 cases were analyzed in this study and divided in two groups: a) 9 responder and b) 6 non-responder/non-treated. Results: Quantitative analysis of ESR, CRP, and bone scan before and after the 10-14 day interval showed no significant change in either group, but a quantitative 99m Tc-UBI scan 30, 60, and 120 minutes after tracer injection indicated significant reduction in radiotracer uptake after the 10-14 day interval compared to the 99m Tc-UBI scan before this interval in the responder group, and no significant change in the non-responder/ non -treated group. Conclusion: The 99m Tc-UBI scan can determine response to antibiotic therapy in orthopedic infection in humans.

Item Type: Article
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 27 Apr 2015 09:35
Last Modified: 24 Jun 2017 06:36
URI: http://eprints.goums.ac.ir/id/eprint/3938

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