Golestan University of Medical Sciences Repository

HLA-DRB1*1501 intensifies the impact of IL-6 promoter polymorphism on the susceptibility to multiple sclerosis in an Iranian population

Shahbazi, M. and Roshandel, D. and Ebadi, H. and Fathi, D. and Zamani, M. and Tahmasbifar, A. and Shahbazi, S. (2012) HLA-DRB1*1501 intensifies the impact of IL-6 promoter polymorphism on the susceptibility to multiple sclerosis in an Iranian population. EUROPEAN JOURNAL OF NEUROLOGY, 19 (1, SI). p. 705.

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Abstract

Background: The multifunctional cytokine interleukin-6 (IL-6) is involved in inflammatory processes in the central nervous system. It is well documented that the amount of IL-6 is increased in serum, cerebrospinal fluid and central nervous system lesions of patients with multiple sclerosis. A single nucleotide polymorphism at position -174 in the IL-6 gene promotor appears to influence IL-6 expression. Recently, several researchers have focused on HLA-DRB alleles, specifically HLA-DRB1*1501, as a potential risk allele in the pathogenesis of multiple sclerosis. Method: Genomic DNA was extracted from whole blood of 345 patients with multiple sclerosis and 426 control subjects. The SSP-PCR method was used to determine genotypes and Fisher’s exact test was applied to determine differences between groups. HL Results: A-DRB1*1501 was observed more frequently among multiple sclerosis patients compared with healthy subjects (45% and 34%, respectively; OR=1.6, 95% CI=1.2- 2.2, p=0.0018). At the IL-6/-174 position, the G allele had higher frequency among multiple sclerosis patients compared with controls (77% and 70%, respectively; OR=1.4, 95% CI=1.1-1.8, p=0.0038). This difference was more significant among HLA-DRB1*1501-positive patients and controls (81% and 67%, respectively; OR=1.9, 95% CI=1.5-2.5, p<0.0001). Discussion: Our results have shown that the G allele at the IL-6/-174 promoter polymorphism may be associated with development of multiple sclerosis in this population, and may be strengthened by HLA-DRB1*1501. Conclusions: We suggest more studies to confirm these results in other populations

Item Type: Article
Additional Information: 16th Congress of the European-Federation-of-Neurological-Societies (EFNS), Stockholm, SWEDEN, SEP 08-11, 2012
Subjects: موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 27 Apr 2015 08:48
Last Modified: 25 Jun 2017 05:41
URI: http://eprints.goums.ac.ir/id/eprint/3847

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