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Opium, tobacco, and alcohol use in relation to oesophageal squamous cell carcinoma in a high-risk area of Iran

Nasrollahzadeh, D. and Kamangar, F. and Aghcheli, K. and Sotoudeh, M. and Islami, F. and Abnet, C.C. and Shakeri, R. and Pourshams, A. and Marjani, H.A. and Nouraie, M. and Khatibian, M. and Semnani, S. and Ye, W. and Boffetta, P. and Dawsey, S.M. and Malekzadeh, R. (2008) Opium, tobacco, and alcohol use in relation to oesophageal squamous cell carcinoma in a high-risk area of Iran. British Journal of Cancer, 98 (11). pp. 1857-1863.

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Abstract

The very high incidence of oesophageal squamous cell carcinoma (ESCC) in Golestan Province in northeastern Iran was suggested by studies in the 1970s as partly due to opium use, which is not uncommon in this area, but based on limited numbers. From December 2003 to June 2007, we administered a validated structured questionnaire to 300 ESCC cases and 571 controls, matched on neighbourhood of residence, age (±2 years), and sex. We used conditional logistic regression models to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs) adjusted for potential confounders. Compared with those who used neither tobacco nor opium, risk of ESCC was increased in those who used tobacco only (OR, 95% CI: 1.70, 1.05-2.73), in those who used opium only (2.12, 1.21-3.74), and in those who used both tobacco and opium (2.35, 1.50-3.67). All forms of tobacco use (cigarettes, hookah, and nass) were associated with higher ESCC risk. Similarly, use of both crude opium and other forms of opium were associated with higher risk. Alcohol consumption was seen in only 2% of the cases and 2% of the controls, and was not associated with ESCC risk. © 2008 Cancer Research.

Item Type: Article
Additional Information: cited By 102
Uncontrolled Keywords: alcohol; opiate; tobacco smoke, adult; aged; alcohol consumption; article; cancer incidence; cancer risk; cigarette smoking; confidence interval; controlled study; esophageal squamous cell carcinoma; female; human; Iran; logistic regression analysis; major clinical study; male; priority journal; questionnaire, Adult; Aged; Alcohol Drinking; Carcinoma, Squamous Cell; Esophageal Neoplasms; Female; Humans; Male; Middle Aged; Mutagens; Opium; Risk Factors; Smoking
Subjects: کهورت
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 21 Apr 2015 10:31
Last Modified: 25 Feb 2017 07:42
URI: http://eprints.goums.ac.ir/id/eprint/2605

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