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Socio-economic status and oesophageal cancer: Results from a population-based case-control study in a high-risk area

Islami, F. and Kamangar, F. and Nasrollahzadeh, D. and Aghcheli, K. and Sotoudeh, M. and Abedi-Ardekani, B. and Merat, S. and Nasseri-Moghaddam, S. and Semnani, S. and Sepehr, A. and Wakefield, J. and Møller, H. and Abnet, C.C. and Dawsey, S.M. and Boffetta, P. and Malekzadeh, R. (2009) Socio-economic status and oesophageal cancer: Results from a population-based case-control study in a high-risk area. International Journal of Epidemiology, 38 (4). pp. 978-988.

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Abstract

Background: Cancer registries in the 1970s showed that parts of Golestan Province in Iran had the highest rate of oesophageal squamous cell carcinoma (OSCC) in the world. More recent studies have shown that while rates are still high, they are approximately half of what they were before, which might be attributable to improved socio-economic status (SES) and living conditions in this area. We examined a wide range of SES indicators to investigate the association between different SES components and risk of OSCC in the region. Methods: Data were obtained from a population-based case-control study conducted between 2003 and 2007 with 300 histologically proven OSCC cases and 571 matched neighbourhood controls. We used conditional logistic regression to compare cases and controls for individual SES indicators, for a composite wealth score constructed using multiple correspondence analysis, and for factors obtained from factors analysis. Results: We found that various dimensions of SES, such as education, wealth and being married were all inversely related to OSCC. The strongest inverse association was found with education. Compared with no education, the adjusted odds ratios (95 confidence intervals) for primary education and high school or beyond were 0.52 (0.27-0.98) and 0.20 (0.06-0.65), respectively. Conclusions: The strong association of SES with OSCC after adjustment for known risk factors implies the presence of yet unidentified risk factors that are correlated with our SES measures; identification of these factors could be the target of future studies. Our results also emphasize the importance of using multiple SES measures in epidemiological studies. Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2009; all rights reserved.

Item Type: Article
Additional Information: cited By 54
Uncontrolled Keywords: cancer; correspondence analysis; disease control; epidemiology; factor analysis; histology; living standard; regression analysis; risk factor; socioeconomic status, adult; article; cancer risk; controlled study; educational status; esophagus cancer; ethnicity; female; high risk population; human; major clinical study; male; marriage; population based case control study; priority journal; social status; urban area, Aged; Carcinoma, Squamous Cell; Educational Status; Epidemiologic Methods; Esophageal Neoplasms; Female; Humans; Iran; Male; Middle Aged; Social Class; Socioeconomic Factors, Asia; Eurasia; Golestan; Iran; Middle East
Subjects: کهورت
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 21 Apr 2015 10:29
Last Modified: 01 Mar 2017 05:45
URI: http://eprints.goums.ac.ir/id/eprint/2604

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