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Tooth loss and lack of regular oral hygiene are associated with higher risk of esophageal squamous cell carcinoma

Abnet, C.C. and Kamangar, F. and Islami, F. and Nasrollahzadeh, D. and Brennan, P. and Aghcheli, K. and Merat, S. and Pourshams, A. and Marjani, H.A. and Ebadati, A. and Sotoudeh, M. and Boffetta, P. and Malekzadeh, R. and Dawsey, S.M. (2008) Tooth loss and lack of regular oral hygiene are associated with higher risk of esophageal squamous cell carcinoma. Cancer Epidemiology Biomarkers and Prevention, 17 (11). pp. 3062-3068.

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Abstract

We tested the association between tooth loss and oral hygiene and the risk of esophageal squamous cell carcinoma (ESCC) in people living in a high-risk area of Iran. We used a case-control study of pathologically confirmed ESCC cases (n = 283) and controls (n = 560) matched on sex, age, and neighborhood. Subjects with ESCC had significantly more decayed, missing, or filled teeth (DMFT) with a median (interquartile range) of 31 (23-32) compared with controls 28 (16-32; P = 0.0045). Subjects with ESCC were significantly more likely than controls to fail to practice regular oral hygiene (78 versus 58). In multivariate-adjusted conditional logistic regression models, having 32 DMFT compared with ≤15 conferred an odds ratio (95 confidence interval) of 2.10 (1.19-3.70). Compared with daily tooth brushing, practicing no regular oral hygiene conferred an odds ratio (95 confidence interval) of 2.37 (1.42-3.97). Restricting the analysis to subjects that had never smoked tobacco did not materially alter these results. We found significant associations between two markers of poor oral hygiene, a larger number of DMFT and lack of daily tooth brushing, and risk of ESCC in a population at high risk for ESCC where many cases occur in never smokers. Our results are consistent with several previous analyses in other high-risk populations. Copyright © 2008 American Association for Cancer Research.

Item Type: Article
Additional Information: cited By 55
Uncontrolled Keywords: adult; aged; article; cancer risk; case control study; clinical article; comorbidity; controlled study; dental caries; disease association; esophageal squamous cell carcinoma; female; high risk population; human; male; mouth hygiene; periodontal disease; priority journal; smoking; tooth brushing; tooth filling, Aged; Carcinoma, Squamous Cell; Case-Control Studies; Chi-Square Distribution; Esophageal Neoplasms; Female; Humans; Iran; Logistic Models; Male; Middle Aged; Oral Health; Physical Examination; Precancerous Conditions; Questionnaires; Risk Factors; Tooth Loss
Subjects: کهورت
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 21 Apr 2015 09:31
Last Modified: 25 Feb 2017 06:43
URI: http://eprints.goums.ac.ir/id/eprint/2601

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