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Large body size and sedentary lifestyle during childhood and early adulthood and esophageal squamous cell carcinoma in a high-risk population

Etemadi, A. and Golozar, A. and Kamangar, F. and Freedman, N.D. and Shakeri, R. and Matthews, C. and Islami, F. and Boffetta, P. and Brennan, P. and Abnet, C.C. and Malekzadeh, R. and Dawsey, S.M. (2012) Large body size and sedentary lifestyle during childhood and early adulthood and esophageal squamous cell carcinoma in a high-risk population. Annals of Oncology, 23 (6). pp. 1593-1600.

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Abstract

Background: Little is known about the association of obesity and physical activity at young ages with subsequent risk of esophageal squamous cell carcinoma (ESCC). Patients and methods: Between 2003 and 2007, we conducted a case-control study in a high-risk population in northeastern Iran. Three hundred ESCC cases and 571 matched controls were recruited. Each individual was shown a standard pictogram, to report body size at ages 15 and 30. Demographic and health-related information, including physical activity at these ages was also collected. Results: In the fully adjusted models, very obese body size (last two pictograms) at age 15 odds ratio (OR) 3.2, 95% confidence interval (CI) 1.3-7.7 and age 30 (OR 3.1; 95% CI 1.1-8.5) were associated with ESCC in women, but not in men. Sedentary work at age 15 (OR 3.3, 95% CI 1.3-8.3) and 30 (OR 18.2, 95% CI 3.9-86.2) were also associated with ESCC risk in women only. The increased risk in women at age 15 remained high after later reduction in body size, while women who became very obese only at age 30 did not show a significantly increased risk. Conclusion: These results highlight the importance of early lifestyle modifications in the context of cancer prevention, particularly in women. © Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.

Item Type: Article
Additional Information: cited By 9
Uncontrolled Keywords: adolescent; adult; adulthood; article; body size; case control study; childhood; controlled study; disease association; esophageal squamous cell carcinoma; female; high risk population; human; major clinical study; male; obesity; physical activity; priority journal; risk assessment; risk factor; sedentary lifestyle; sex difference, Adult; Aged; Carcinoma, Squamous Cell; Case-Control Studies; Child; Esophageal Neoplasms; Female; Humans; Logistic Models; Male; Middle Aged; Obesity; Odds Ratio; Risk Factors; Rural Population; Sedentary Lifestyle
Subjects: کهورت
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 21 Apr 2015 06:57
Last Modified: 19 May 2015 03:57
URI: http://eprints.goums.ac.ir/id/eprint/2593

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