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Golestan cohort study of oesophageal cancer: Feasibility and first results

Pourshams, A. and Saadatian-Elahi, M. and Nouraie, M. and Malekshah, A.F. and Rakhshani, N. and Salahi, R. and Yoonessi, A. and Semnani, S. and Islami, F. and Sotoudeh, M. and Fahimi, S. and Sadjadi, A.R. and Nasrollahzadeh, D. and Aghcheli, K. and Kamangar, F. and Abnet, C.C. and Saidi, F. and Sewram, V. and Strickland, P.T. and Dawsey, S.M. and Brennan, P. and Boffetta, P. and Malekzadeh, R. (2005) Golestan cohort study of oesophageal cancer: Feasibility and first results. British Journal of Cancer, 92 (1). pp. 176-181. ISSN 00070920

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Abstract To investigate the incidence of oesophageal cancer (EC) in the Golestan province of North-East Iran, we invited 1349 rural and urban inhabitants of Golestan province aged 35-80 to undergo extensive lifestyle interviews and to provide biological samples. The interview was repeated on a subset of 130 participants to assess reliability of questionnaire and medical information. Temperature at which tea was consumed was measured on two occasions by 110 subjects. Samples of rice, wheat and sorghum were tested for fumonisin contamination. An active follow-up was carried out after 6 and 12 months. A total of 1057 subjects (610 women and 447 men) participated in this feasibility study (78.4% participation rate). Cigarette smoking, opium and alcohol use were reported by 163 (13.8%), 93 (8.8%) and 39 (3.7%) subjects, respectively. Tobacco smoking was correlated with urinary cotinine (κ = 0.74). Most questionnaire data had κ > 0.7 in repeat measurements; tea temperature measurement was reliable (κ = 0.71). No fumonisins were detected in the samples analysed. During the follow-up six subjects were lost (0.6%), two subjects developed EC (one dead, one alive); in all, 13 subjects died (with cause of death known for 11, 84.6%). Conducting a cohort study in Golestan is feasible with reliable information obtained for suspected risk factors; participants can be followed up for EC incidence and mortality. © 2005 Cancer Research UK.

Item Type: Article
Additional Information: cited By 56
Uncontrolled Keywords: cotinine; fumonisin, adult; aged; article; cancer incidence; cancer mortality; cohort analysis; controlled study; esophagus cancer; feasibility study; female; human; interview; Iran; lifestyle; major clinical study; male; medical information; priority journal; questionnaire; reliability; rice; risk factor; smoking; sorghum; tea; wheat, Adult; Aged; Alcohol Drinking; Cohort Studies; Esophageal Neoplasms; Feasibility Studies; Female; Food Habits; Humans; Incidence; Iran; Life Style; Male; Middle Aged; Opium; Risk Factors; Smoking; Tea
Subjects: هیئت علمی
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 21 Apr 2015 06:34
Last Modified: 16 Apr 2018 09:43
URI: http://eprints.goums.ac.ir/id/eprint/2591

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