Golestan University of Medical Sciences Repository

The prevalence of hepatitis B surface antigen and anti-hepatitis B core antibody in Iran: A population-based study

Merat, S. and Rezvan, H. and Nouraie, M. and Jamali, J. and Assari, S. and Abolghasemi, H. and Radmard, A.R. and Zaer-Rezaii, H. and Zeid-Abadi-Nejhad, M. and Hosseini, M.R. and Amini-Kafiabad, S. and Maghsudlu, M. and Pourshams, A. and Malekzadeh, R. (2009) The prevalence of hepatitis B surface antigen and anti-hepatitis B core antibody in Iran: A population-based study. Archives of Iranian Medicine, 12 (3). pp. 225-231.

[img]
Preview
PDF - Published Version
Download (295kB) | Preview

Abstract

Background: Hepatitis B virus infection is a very common cause of chronic liver disease worldwide. It is estimated that 3 of Iranians are chronically infected with hepatitis B virus. Current population-based studies on both rural and urban prevalence of hepatitis B virus infection in Iran are sparse with results that do not always agree. We performed this study to find the prevalence of hepatitis B surface antigen, anti-hepatitis B core antibody, and associated factors in the general population of three provinces of Iran. Methods: We randomly selected 6,583 subjects from three provinces in Iran, namely Tehran, Golestan, and Hormozgan. The subjects were aged between 18 and 65 years. Serum samples were tested for hepatitis B surface antigen and anti-hepatitis B core antibody. Various risk factors were recorded and multivariate analysis was performed. Results: The prevalence of hepatitis B surface antigen and anti-hepatitis B core antibody in Iran was 2.6 and 16.4, respectively. Predictors of hepatitis B surface antigen or anti-hepatitis B core antibody in multivariate analysis included older age, not having high-school diploma, living in a rural area, and liver disease in a family member. We did not find any significant differences between males and females. Conclusion: In spite of nationwide vaccination of newborns against hepatitis B virus since 1992, hepatitis B virus infection remains a very common cause of chronic liver disease in Iran which should be dealt with for at least the next 30-50 years.

Item Type: Article
Additional Information: cited By 52
Uncontrolled Keywords: hepatitis B core antibody; hepatitis B surface antigen; hepatitis B vaccine; hepatitis B antibody; hepatitis B surface antigen, adult; aged; article; blood analysis; clinical trial; controlled clinical trial; controlled study; female; geographic distribution; hepatitis B; Hepatitis B virus; high school student; human; Iran; major clinical study; male; multivariate analysis; population based case control study; prevalence; randomized controlled trial; risk factor; rural area; sex difference; urban area; vaccination; adolescent; age distribution; comparative study; cross-sectional study; health survey; hepatitis B; Hepatitis B virus; immunology; Iran; middle aged; sex ratio; virology, Adolescent; Adult; Age Distribution; Aged; Cross-Sectional Studies; Female; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Iran; Male; Middle Aged; Population Surveillance; Prevalence; Sex Distribution; Young Adult
Subjects: کهورت
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 21 Apr 2015 05:41
Last Modified: 01 Mar 2017 06:36
URI: http://eprints.goums.ac.ir/id/eprint/2590

Actions (login required)

View Item View Item