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Familial risks of esophageal cancer among the Turkmen population of the Caspian littoral of Iran

Akbari, M.R. and Malekzadeh, R. and Nasrollahzadeh, D. and Amanian, D. and Sun, P. and Islami, F. and Sotoudeh, M. and Semnani, S. and Boffeta, P. and Dawsey, S.M. and Ghadirian, P. and Narod, S.A. (2006) Familial risks of esophageal cancer among the Turkmen population of the Caspian littoral of Iran. International Journal of Cancer, 119 (5). pp. 1047-1051. ISSN 00207136 (ISSN)

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Abstract

In northeastern Iran, there is an area of high incidence of esophageal cancer, which is populated by residents of Turkmen ancestry. Several environmental risk factors for esophageal cancer have been proposed, but the roles of familial and genetic factors have not been studied extensively in the Turkmen population. We evaluated the importance of familial risk factors for esophageal cancer by performing a case-control study of 167 cases of esophageal squamous cell carcinoma and 200 controls of Turkmen ethnicity. Detailed family pedigrees of the cases and controls were constructed, which documented all cancers in first- and second-degree relatives. The actuarial risk of cancer was then estimated in 2,097 first-degree relatives of cases and 2,783 first-degree relatives of the controls. A hazard ratio was constructed, based on a comparison of the 2 cumulative incidence curves. The risk to age 75 of esophageal cancer in the first-degree relatives of Turkmen patients with esophageal cancer was 34% versus 14% for the first-degree relatives of the controls (hazard ratio = 2.3; p = 3 × 10⁻⁸). Cases (9.6%) reported that their parents were related, versus 2.5% of the controls who reported this, (odds ratio = 4.1; p value = 0.006). Familial factors are important in the etiology of esophageal cancer among the Turkmen residents of Iran. The hazard ratio of 2.3 for cancer among first-degree relatives is consistent with an important contribution of heritable factors. It will be of interest to perform marker studies to establish which genes are responsible. © 2006 Wiley-Liss, Inc.

Item Type: Article
Additional Information: cited By 40
Uncontrolled Keywords: adult; article; cancer risk; case control study; child; controlled study; esophagus cancer; ethnic group; familial cancer; family study; female; heritability; human; major clinical study; male; parent; pedigree analysis; prevalence; priority journal; sibling; Turkey (republic), Actuarial Analysis; Adult; Aged; Carcinoma, Squamous Cell; Case-Control Studies; Esophageal Neoplasms; Female; Genetic Predisposition to Disease; Humans; Incidence; Iran; Male; Middle Aged; Odds Ratio; Pedigree; Risk Assessment; Turkey
Subjects: کهورت
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 21 Apr 2015 04:55
Last Modified: 06 Feb 2017 06:00
URI: http://eprints.goums.ac.ir/id/eprint/2586

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