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Genetic polymorphisms in three Iranian populations with different risks of esophageal cancer, an ecologic comparison

Sepehr, A. and Kamangar, F. and Abnet, C.C. and Fahimi, S. and Pourshams, A. and Poustchi, H. and Zeinali, S. and Sotoudeh, M. and Islami, F. and Nasrollahzadeh, D. and Malekzadeh, R. and Taylor, P.R. and Dawsey, S.M. (2004) Genetic polymorphisms in three Iranian populations with different risks of esophageal cancer, an ecologic comparison. Cancer Letters, 213 (2). pp. 195-202. ISSN 03043835

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The age-standardized incidence of esophageal cancer (EC) varies from 3 to >100/100,000 per year in different provinces of Iran. This striking variation of incidence is associated with differences in ethnic backgrounds, raising the possibility that genetic factors are involved in the pathogenesis of EC. We compared the frequencies of polymorphisms in ten genes that have been hypothesized to have a role in risk of EC (CYP1A1, CYP2A6, CYP2E1, GSTM1, GSTP1, GSTT1, ADH2, ADH3, ALDH2, and O 6-MGMT) among three Iranian ethnic groups with highly varying rates of EC. These three groups included high-risk Turkomans, medium-risk Turks, and low-risk Zoroastrian Persians. Compared to Zoroastrians, Turkomans had higher frequency of four alleles that are speculated to favor carcinogenesis (CYP1A1 m1, CYP1A1 m2, CYP2A6*9, and ADH2*1); these results are consistent with an influence of these allele variants on the population risk of EC. However, none of these four alleles had a high enough prevalence in Turkomans to explain the high rates of EC in this group. Three of these four alleles (CYP1A1 m1, CYP1A1 m2, CYP2A6*9) were less frequent among Turkomans than in some Asian populations with lower risks of EC. We conclude that it is unlikely that variations in these polymorphic genes are major contributors to the high incidence of EC among Turkomans in Iran. © 2004 Elsevier Ireland Ltd. All rights reserved.

Item Type: Article
Additional Information: cited By 26
Uncontrolled Keywords: aldehyde dehydrogenase isoenzyme 2; cytochrome P450 1A1; cytochrome P450 2A6; glutathione transferase; methylated DNA protein cysteine methyltransferase, adult; allele; article; Asia; cancer incidence; cancer risk; carcinogenesis; controlled study; ecosystem; esophagus cancer; ethnic group; female; gene expression; genetic analysis; genetic polymorphism; genetic variability; high risk population; human; Iran; major clinical study; male; prevalence; priority journal, Asia; Ecology; Enzymes; Esophageal Neoplasms; Genetic Predisposition to Disease; Genetics, Population; Humans; Incidence; Iran; Polymorphism, Genetic; Risk Factors, Irania
Subjects: کهورت
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 21 Apr 2015 04:16
Last Modified: 16 Apr 2018 09:45
URI: http://eprints.goums.ac.ir/id/eprint/2582

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