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The impact of illicit drug use on Spontaneous Hepatitis C Clearance: Experience from a large cohort population study

Poustchi, H. and Esmaili, S. and Mohamadkhani, A. and Nikmahzar, A. and Pourshams, A. and Sepanlou, S.G. and Merat, S. and Malekzadeh, R. (2011) The impact of illicit drug use on Spontaneous Hepatitis C Clearance: Experience from a large cohort population study. PLoS ONE, 6 (8).

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Abstract

Background and Aims: Acute hepatitis C infection usually ends in chronic infection, while in a minority of patients it is spontaneously cleared. The current population-based study is performed on a large cohort in Golestan province of Iran to examine the demographic correlates of Spontaneous Hepatitis C Clearance. Methods: Serum samples used in this study had been stored in biorepository of Golestan Cohort Study. These samples were evaluated for anti hepatitis C Virus by third generation Enzyme-linked immunosorbent assay (ELISA). Subjects who tested positive were then invited and tested by Recombinant Immunoblot Assay (RIBA) and Ribonucleic Acid Polymerase Chain Reaction test (PCR). If tested positive for RIBA, subjects were recalled and the two tests were re-done after 6 months. Those subjects who again tested positive for RIBA but negative for PCR were marked as cases of spontaneous clearance. Results: 49,338 serum samples were evaluated. The prevalence of Chronic Hepatitis C Virus (CHCV) infection based on PCR results was 0.31. Among those who had acquired hepatitis C, the rate of SC was 38. In multivariate analysis, illicit drug use both Injecting Use (OR = 3.271, 95 CI: 1.784-6.000, p-value<0.001) and Non-Injecting Use (OR = 1.901, 95 CI: 1.068-3.386, p-value = 0.029) were significant correlates of CHCV infection versus SC. Conclusions: Illicit drug use whether intravenous or non-intravenous is the only significant correlate of CHCV, for which several underlying mechanisms can be postulated including repeated contacts with hepatitis C antigen. © 2011 Poustchi et al.

Item Type: Article
Additional Information: cited By 5
Uncontrolled Keywords: hepatitis C antibody; illicit drug, adult; article; cohort analysis; controlled study; correlation analysis; drug abuse; enzyme linked immunosorbent assay; female; hepatitis C; human; immunoblotting; intravenous drug abuse; Iran; major clinical study; male; polymerase chain reaction; population research; prevalence; viral clearance; addiction; hepatitis C; Iran; middle aged; pathology; remission, Hepatitis C virus, Cohort Studies; Female; Hepatitis C; Humans; Iran; Male; Middle Aged; Remission, Spontaneous; Substance-Related Disorders
Subjects: کهورت
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 21 Apr 2015 04:01
Last Modified: 16 May 2015 11:04
URI: http://eprints.goums.ac.ir/id/eprint/2581

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