Golestan University of Medical Sciences Repository

The upper normal limit of serum alanine aminotransferase in Golestan Province, Northeast Iran

Jamali, R. and Pourshams, A. and Amini, S. and Deyhim, M.R. and Rezvan, H. and Malekzadeh, R. (2008) The upper normal limit of serum alanine aminotransferase in Golestan Province, Northeast Iran. Archives of Iranian Medicine, 11 (6). pp. 602-607.

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Abstract

Background: The objective of this study was to determine the upper normal limit of serum alanine aminotransferase level in a population-based study in Golestan Province, northeast Iran. Methods: From the randomly invited individuals (2,292), 698 out of the 916 males and 1,351 out of the 1,376 females participated in the study (participation rate: 76.2 and 98.1, respectively). One hundred and twenty-one participants were excluded due to positive hepatitis B surface antigen or hepatitis C virus antibody and/or drinking more than 20 grams of alcohol per day. A total of 1,928 participants (1300 females) were included. The upper normal limit of serum alanine aminotransferase level was defined as the 95th percentile. Results: The upper normal limit of serum alanine aminotransferase level in normal weight and nondiabetics was significantly lower than the total study group (36 versus 45 U/L). Serum alanine aminotransferase level was independently associated with male gender, body mass index, and diabetes mellitus (OR=2.05; 95Cl: 1.44 - 2.94, OR=2.76; 95Cl: 1.84 - 4.13, and OR=2.96; 95Cl: 1.56-5.61, respectively). Conclusion: Considering the lower calculated upper normal limit in normal weight nondiabetic participants in this study, we recommend setting new upper normal limit for serum alanine aminotransferase level, It seems reasonable to set upper normal limit for serum alanine aminotransferase level in males and females separately.

Item Type: Article
Additional Information: cited By 16
Uncontrolled Keywords: alanine aminotransferase; hepatitis B surface antigen; hepatitis C antibody, adult; aged; alanine aminotransferase blood level; alcohol consumption; article; blood analysis; body mass; body weight; controlled study; diabetes mellitus; drinking behavior; female; human; hyperphenylalaninemia; Iran; major clinical study; male; normal value; population research; sex difference, Adolescent; Adult; Aged; Alanine Transaminase; Blood Glucose; Body Mass Index; Chemistry, Clinical; Diabetes Mellitus; Female; Humans; Iran; Male; Middle Aged; Reference Values; Risk Factors; Sex Factors; Young Adult
Subjects: کهورت
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 08:08
Last Modified: 25 Feb 2017 07:09
URI: http://eprints.goums.ac.ir/id/eprint/2567

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