Golestan University of Medical Sciences Repository

Dietary intake of benzo(a)pyrene and risk of esophageal cancer in north of Iran

Hakami, R. and Mohtadinia, J. and Etemadi, A. and Kamangar, F. and Nemati, M. and Pourshams, A. and Islami, F. and Nasrollahzadeh, D. and Saberi-Firoozi, M. and Birkett, N. and Boffetta, P. and Malekzadeh, R. (2008) Dietary intake of benzo(a)pyrene and risk of esophageal cancer in north of Iran. Nutrition and Cancer, 60 (2). pp. 216-221.

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Abstract

One etiologic factor for high incidence of esophageal squamous cell carcinoma (ESCC) in Golestan (Northeastern Iran) might be exposure to polycyclic aromatic hydrocarbons. We examined whether food and water are major sources of benzo(a)pyrene (BaP) exposure in this population. We used a dietary questionnaire to assess the daily intake of staple food (rice and bread) and water in 3 groups: 40 ESCC Golestan cases, 40 healthy subjects from the same area, and 40 healthy subjects from a low-risk area in Southern Iran. We measured, by high-performance liquid chromatography combined with fluorescence detection, the BaP concentration of bread, rice, and water in samples obtained from these 3 groups and calculated the daily intake of BaP. Mean BaP concentration of staple foods and water was similar and within standard levels in both areas, but the daily intake of BaP was higher in controls from the high-risk area than in controls from the low-risk area (91.4 vs. 70.6 ng/day, P < 0.01). In the multivariate regression analysis, having ESCC had no independent effect on BaP, whereas residence in the low-risk area was associated with a significant decrease in total BaP intake. Polycyclic aromatic hydrocarbons might, along with other risk factors, contribute to the high risk of ESCC in Golestan. Copyright © 2008, Taylor & Francis Group, LLC.

Item Type: Article
Additional Information: cited By 29
Uncontrolled Keywords: benzoapyrene; polycyclic aromatic hydrocarbon, adult; article; bread; calculation; cancer risk; clinical article; concentration (parameters); controlled study; dietary intake; esophagus cancer; female; fluid intake; fluorescence analysis; food intake; high performance liquid chromatography; high risk population; human; Iran; male; multivariate analysis; population exposure; questionnaire; regression analysis; rice; risk factor, Benzo(a)pyrene; Carcinoma, Squamous Cell; Case-Control Studies; Chromatography, High Pressure Liquid; Diet; Diet Surveys; Environmental Exposure; Esophageal Neoplasms; Female; Food Contamination; Humans; Iran; Male; Middle Aged; Questionnaires; Risk Factors; Water Pollutants, Chemical
Subjects: کهورت
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 07:36
Last Modified: 25 Feb 2017 07:40
URI: http://eprints.goums.ac.ir/id/eprint/2566

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