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Exposure to polycyclic aromatic hydrocarbons among never smokers in Golestan Province, Iran, an area of high incidence of esophageal cancer - A cross-sectional study with repeated measurement of urinary 1-OHPG in two seasons

Islami, F. and Boffetta, P. and Van Schooten, F.J. and Strickland, P. and Phillips, D.H. and Pourshams, A. and Malekshah, A.F.-T. and Godschalk, R. and Jafari, E. and Etemadi, A. and Abubaker, S. and Kamangar, F. and Straif, K. and Møller, H. and Schüz, J. and Malekzadeh, R. (2012) Exposure to polycyclic aromatic hydrocarbons among never smokers in Golestan Province, Iran, an area of high incidence of esophageal cancer - A cross-sectional study with repeated measurement of urinary 1-OHPG in two seasons. Frontiers in Oncology, 2 (FEB).

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Abstract

Studies have suggested a possible role of polycyclic aromatic hydrocarbons (PAHs) in the etiology of esophageal cancer in Golestan Province, Iran, where incidence of this cancer is very high. In order to investigate the patterns of non-smoking related exposure to PAHs in Golestan, we conducted a cross-sectional study collecting questionnaire data, genotyping polymorphisms related to PAH metabolism, and measuring levels of 1-hydroxypyrene glucuronide (1-OHPG), a PAH metabolite, in urine samples collected in two seasons from the same group of 111 randomly selected never-smoking women. Beta-coefficients for correlations between 1-OHPG as dependent variable and other variables were calculated using linear regression models. The creatinine-adjusted 1-OHPG levels in both winter and summer samples were approximately 110 μmol/molCr (P for seasonal difference = 0.40). In winter, red meat intake (β = 0.208; P = 0.03), processed meat intake (β = 0.218; P = 0.02), and GSTT1-02 polymorphism ("null" genotype: β = 0.228; P = 0.02) showed associations with 1-OHPG levels, while CYP1B1-07 polymorphism (GG versus AA + GA genotypes: β = -0.256; P = 0.008) showed an inverse association. In summer, making bread at home (> weekly versus never: β = 0.203; P = 0.04), second-hand smoke (exposure to ≥3 cigarettes versus no exposure: β = 0.254; P = 0.01), and GSTM1-02 "null" genotype (β = 0.198; P = 0.04) showed associations with 1-OHPG levels, but GSTP1-02 polymorphism (CT + TT versus CC: β = -0.218; P = 0.03) showed an inverse association. This study confirms high exposure of the general population in Golestan to PAHs and suggests that certain foods, cooking methods, and genetic polymorphisms increase exposure to PAHs. © 2012 Islami, Boffetta, van Schooten, Strickland, Phillips, Pourshams, Fazel-Tabar Malekshah, Godschalk, Jafari, Etemadi, Abubaker, Kamangar, Straif, Møller, Schüz and Malekzadeh.

Item Type: Article
Additional Information: cited By 3
Uncontrolled Keywords: 1 hydroxypyrene glucuronide; acyltransferase; creatinine; cytochrome P450; glucuronide; glutathione transferase; polycyclic aromatic hydrocarbon; unclassified drug, adult; aged; article; body mass; bread; controlled study; cooking; cross-sectional study; esophageal squamous cell carcinoma; esophagus cancer; female; fluorescence spectroscopy; food intake; frying; genetic polymorphism; genotyping technique; human; Iran; major clinical study; male; middle aged; polymerase chain reaction; questionnaire; red meat; season; smoking; urinalysis
Subjects: کهورت
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 07:21
Last Modified: 15 Jun 2015 07:09
URI: http://eprints.goums.ac.ir/id/eprint/2563

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