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Opium use and mortality in Golestan Cohort Study: prospective cohort study of 50,000 adults in Iran.

Khademi, H. and Malekzadeh, R. and Pourshams, A. and Jafari, E. and Salahi, R. and Semnani, S. and Abaie, B. and Islami, F. and Nasseri-Moghaddam, S. and Etemadi, A. and Byrnes, G. and Abnet, C.C. and Dawsey, S.M. and Day, N.E. and Pharoah, P.D. and Boffetta, P. and Brennan, P. and Kamangar, F. (2012) Opium use and mortality in Golestan Cohort Study: prospective cohort study of 50,000 adults in Iran. BMJ (Clinical research ed.), 344. e2502.

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Abstract

To investigate the association between opium use and subsequent risk of death. Prospective cohort study. The Golestan Cohort Study in north-eastern Iran collected detailed validated data on opium use and other exposures at baseline. Participants were enrolled between January 2004 and June 2008 and were followed to May 2011, with a follow-up success rate of over 99. 50,045 participants aged 40-75 at baseline. Mortality, all cause and major subcategories. 17 (n = 8487) of the participants reported opium use, with a mean duration of 12.7 years. During the follow-up period 2145 deaths were reported. The adjusted hazard ratio for all cause mortality associated with ever use of opium was 1.86 (95 confidence interval 1.68 to 2.06). Opium consumption was significantly associated with increased risks of deaths from several causes including circulatory diseases (hazard ratio 1.81) and cancer (1.61). The strongest associations were seen with deaths from asthma, tuberculosis, and chronic obstructive pulmonary disease (11.0, 6.22, and 5.44, respectively). After exclusion of people who self prescribed opium after the onset of major chronic illnesses, the associations remained strong with a dose-response relation. Opium users have an increased risk of death from multiple causes compared with non-users. Increased risks were also seen in people who used low amounts of opium for a long period and those who had no major illness before use.

Item Type: Article
Additional Information: cited By 26
Uncontrolled Keywords: opiate, adult; article; cause of death; dose response; female; follow up; health survey; human; Iran; male; mortality; opiate addiction; proportional hazards model; prospective study; questionnaire, Adult; Cause of Death; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Health Surveys; Humans; Iran; Male; Opioid-Related Disorders; Opium; Proportional Hazards Models; Prospective Studies; Questionnaires
Subjects: کهورت
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 06:22
Last Modified: 12 May 2015 05:37
URI: http://eprints.goums.ac.ir/id/eprint/2560

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