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Ecologic study of serum selenium and upper gastrointestinal cancers in Iran

Nouarie, M. and Pourshams, A. and Kamangar, F. and Sotoudeh, M. and Derakhshan, M.H. and Akbari, M.R. and Fakheri, H. and Zahedi, M.J. and Caldwell, K. and Abnet, C.C. and Taylor, P.R. and Malekzadeh, R. and Dawsey, S.M. (2004) Ecologic study of serum selenium and upper gastrointestinal cancers in Iran. World Journal of Gastroenterology, 10 (17). pp. 2544-2546. ISSN 10079327

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Aim: Both observational and experimental studies have shown that higher selenium status reduces the risk of upper gastrointestinal cancers in selenium deficient populations. Recent cancer registry data have shown very different rates of esophageal cancer (EC) and gastric cancer (GC) in four Provinces of Iran, namely Ardabil, Mazandaran, Golestan, and Kerman. The aim of this study was to have a preliminary assessment of the hypothesis that high rates of EC in Golestan and high rates of GC in Ardabil may be partly attributable to selenium deficiency. Methods: We measured serum selenium in 300 healthy adults from Ardabil (n = 100), Mazandaran (n = 50), Golestan (n = 100), and Kerman (n = 50), using inductively coupled plasma, with dynamic reaction cell, mass spectrometry (ICP-DRC-MS) at the US Centers for Disease Control (Atlanta, Georgia). Results: The median serum selenium concentrations were very different in the four Provinces. The medians (IQR) for selenium in Ardabil, Mazandarn, Golestan, and Kerman were 82 (75-94), 123 (111-132), 155 (141-173), and 119 (110-128) μg/L, respectively (P<0.001). The results of linear regression showed that the Province variable, by itself, explained 76% of the variance in log selenium (r2 = 0.76). The proportion of the populations with a serum selenium more than 90 μg/L (the concentration at which serum selenoproteins are saturated) was 100% in Golestan, Kerman, and Mazandaran but only 29% in Ardabil. Conclusion: Our findings suggest that selenium deficiency is not a major contributor to the high incidence of EC seen in northeastern Iran, but it may play a role in the high incidence of GC in Ardabil Province. Copyright © 2004 by The WJG Press.

Item Type: Article
Additional Information: cited By 39
Uncontrolled Keywords: selenium; selenium, adult; analysis of variance; article; cancer incidence; community ecology; controlled study; esophagus cancer; female; human; hypothesis; Iran; linear regression analysis; major clinical study; male; medical assessment; mineral blood level; selenium deficiency; statistical significance; stomach cancer; upper gastrointestinal tract; blood; esophagus tumor; incidence; Iran; middle aged; risk factor; statistical model; stomach tumor, Adult; Esophageal Neoplasms; Female; Humans; Incidence; Iran; Linear Models; Male; Middle Aged; Risk Factors; Selenium; Stomach Neoplasms
Subjects: کهورت
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 04:35
Last Modified: 16 Apr 2018 09:02
URI: http://eprints.goums.ac.ir/id/eprint/2555

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