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Gastric atrophy and oesophageal squamous cell carcinoma: Possible interaction with dental health and oral hygiene habit

Nasrollahzadeh, D. and Malekzadeh, R. and Aghcheli, K. and Sotoudeh, M. and Merat, S. and Islami, F. and Kamangar, F. and Abnet, C.C. and Shakeri, R. and Pourshams, A. and Semnani, S. and Boffetta, P. and Dawsey, S.M. and Ye, W. (2012) Gastric atrophy and oesophageal squamous cell carcinoma: Possible interaction with dental health and oral hygiene habit. British Journal of Cancer, 107 (5). pp. 888-894.

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Abstract

Background:Gastric fundal atrophy has been hypothesised to increase the risk of oesophageal squamous cell carcinoma (OSCC), but studies have shown inconsistent results.Methods:We measured serum pepsinogen I (PGI) and pepsinogen II (PGII) among 293 incident cases and 524 matched neighbourhood controls in a high-risk area of Northern Iran. Conditional logistic regression model was used to estimate odds ratios (ORs) and their 95 confidence intervals (CIs).Results:After controlling for age, sex, residence area and other potential confounders, gastric atrophy (defined by a validated criterion, PGI <55 μg dl-1) was associated with a two-fold increased risk (OR=2.01, 95 CI: 1.18, 3.45) of OSCC in the absence of nonatrophic pangastritis (defined as PGII <11.8 μg dl-1). Stratification by PGII decreased the misclassification errors due to cancer-induced gastritis. Presence of both poor dental health, indicated by higher than median sum of decayed, missing, and filled teeth (DMFT score), and gastric atrophy further increased the risk of OSCC (OR=4.15, 95 CI: 2.04, 8.42) with relative excess risk due to interaction (RERI) of 1.47 (95 CI: 1.15, 4.1). Coexistence of poor oral hygiene habit with gastric atrophy elevated OSCC risk eight times (OR=8.65, 95 CI: 3.65, 20.46) and the additive interaction index was marginally statistically significant (RERI=4.34, 95 CI: 1.07, 9.76).Conclusion:Gastric atrophy is a risk factor for OSCC, and poor dental health and oral hygiene habit may act synergistically in increasing the risk. © 2012 Cancer Research UK.

Item Type: Article
Additional Information: cited By 3
Uncontrolled Keywords: pepsinogen I; pepsinogen II, adult; aged; article; cancer risk; controlled study; dental caries; dental health; disease association; enzyme blood level; esophageal squamous cell carcinoma; female; gastritis; habit; human; Iran; major clinical study; male; mouth hygiene; priority journal; risk assessment; stomach atrophy; tooth filling, Carcinoma, Squamous Cell; Case-Control Studies; Esophageal Neoplasms; Female; Gastritis, Atrophic; Humans; Male; Middle Aged; Oral Hygiene; Pepsinogen A; Pepsinogen C; Questionnaires; Risk Factors
Subjects: کهورت
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 04:31
Last Modified: 07 Jun 2015 04:05
URI: http://eprints.goums.ac.ir/id/eprint/2554

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