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Epidemiologic features of upper gastrointestinal tract cancers in Northeastern Iran

Islami, F. and Kamangar, F. and Aghcheli, K. and Fahimi, S. and Semnani, S. and Taghavi, N. and Marjani, H.A. and Merat, S. and Nasseri-Moghaddam, S. and Pourshams, A. and Nouraie, M. and Khatibian, M. and Abedi, B. and Brazandeh, M.H. and Ghaziani, R. and Sotoudeh, M. and Dawsey, S.M. and Abnet, C.C. and Taylor, P.R. and Malekzadeh, R. (2004) Epidemiologic features of upper gastrointestinal tract cancers in Northeastern Iran. British Journal of Cancer, 90 (7). pp. 1402-1406.

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Abstract

Previous studies have shown that oesophageal and gastric cancers are the most common causes of cancer death in the Golestan Province, Iran. In 2001, we established Atrak Clinic, a referral clinic for gastrointestinal (GI) diseases in Gonbad, the major city of eastern Golestan, which has permitted, for the first time in this region, endoscopic localisation and histologic examination of upper GI cancers. Among the initial 682 patients seen at Atrak Clinic, 370 were confirmed historically to have cancer, including 223 (60) oesophageal squamous cell cancers (ESCC), 22 (6) oesophageal adenocarcinomas (EAC), 58 (16) gastric cardia adenocarcinomas (GCA), and 58 (16) gastric noncardia adenocarcinomas. The proportional occurrence of these four main site-cell type subdivisions of upper GI cancers in Golestan is similar to that seen in Linxian, China, another area of high ESCC incidence, and is markedly different from the current proportions in many Western countries. Questioning of patients about exposure to some known and suspected risk factors for squamous cell oesophageal cancer confirmed a negligible history of consumption of alcohol, little use of cigarettes or nass (tobacco, lime and ash), and a low intake of opium, suggesting that the high rates of ESCC seen in northeastern Iran must have other important risk factors that remain speculative or unknown. Further studies are needed to define more precisely the patterns of upper GI cancer incidence, to test other previously suspected risk factors, and to find new significant risk factors in this high-risk area. © 2004 Cancer Research UK.

Item Type: Article
Additional Information: cited By 102
Uncontrolled Keywords: calcium oxide; opiate, adult; aged; alcohol consumption; anamnesis; article; ash; cancer mortality; cancer patient; cancer risk; cell type; China; clinical feature; controlled study; esophagus carcinoma; gastrointestinal carcinoma; gastrointestinal endoscopy; histology; human; Iran; major clinical study; male; medical examination; priority journal; risk factor; squamous cell carcinoma; tobacco; upper gastrointestinal tract, Adenocarcinoma; Alcohol Drinking; Carcinoma, Squamous Cell; Cardia; China; Esophageal Neoplasms; Female; History, Early Modern 1451-1600; History, Modern 1601-; Humans; Incidence; Iran; Male; Risk Factors; Smoking; Stomach Neoplasms
Subjects: کهورت
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 04:23
Last Modified: 04 Feb 2017 09:51
URI: http://eprints.goums.ac.ir/id/eprint/2553

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