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Prognostic factors for esophageal squamous cell Carcinoma-A Population-Based study in Golestan province, Iran, a high incidence area

Aghcheli, K. and Marjani, H.A. and Nasrollahzadeh, D. and Islami, F. and Shakeri, R. and Sotoudeh, M. and Abedi-Ardekani, B. and Ghavamnasiri, M.R. and Razaei, E. and Khalilipour, E. and Mohtashami, S. and Makhdoomi, Y. and Rajabzadeh, R. and Merat, S. and Sotoudehmanesh, R. and Semnani, S. and Malekzadeh, R. (2011) Prognostic factors for esophageal squamous cell Carcinoma-A Population-Based study in Golestan province, Iran, a high incidence area. PLoS ONE, 6 (7).

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Abstract

Golestan Province in northern Iran is an area with a high incidence of esophageal squamous cell carcinoma (ESCC). We aimed to investigate prognostic factors for ESCC and survival of cases in Golestan, on which little data were available. We followed-up 426 ESCC cases participating in a population-based case-control study. Data were analyzed using the Kaplan-Meier method and the Cox proportional hazard models. Median survival was 7 months. Age at diagnosis was inversely associated with survival, but the association was disappeared with adjustment for treatment. Residing in urban areas (hazard ratio, HR = 0.70; 95 CI 0.54-0.90) and being of non-Turkmen ethnic groups (HR = 0.76; 95 CI 0.61-0.96) were associated with better prognosis. In contrast to other types of tobacco use, nass (a smokeless tobacco product) chewing was associated with a slightly poorer prognosis even in models adjusted for other factors including stage of disease and treatment (HR = 1.38; 95 CI 0.99-1.92). Opium use was associated with poorer prognosis in crude analyses but not in adjusted models. Almost all of potentially curative treatments were associated with longer survival. Prognosis of ESCC in Golestan is very poor. Easier access to treatment facilities may improve the prognosis of ESCC in Golestan. The observed association between nass chewing and poorer prognosis needs further investigations; this association may suggest a possible role for ingestion of nass constituents in prognosis of ESCC. © 2011 Aghcheli et al.

Item Type: Article
Additional Information: cited By 17
Uncontrolled Keywords: opiate, adult; age; aged; article; cancer chemotherapy; cancer incidence; cancer staging; cancer survival; esophageal squamous cell carcinoma; ethnic group; female; health care access; human; Iran; major clinical study; male; population research; prognosis; smoking; survival rate; survival time; urban area; confidence interval; demography; esophagus tumor; incidence; Iran; middle aged; prognosis; proportional hazards model; squamous cell carcinoma; survival, Nicotiana tabacum, Aged; Carcinoma, Squamous Cell; Confidence Intervals; Demography; Esophageal Neoplasms; Female; Humans; Incidence; Iran; Male; Middle Aged; Prognosis; Proportional Hazards Models; Survival Analysis
Subjects: کهورت
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 04:02
Last Modified: 23 May 2015 06:09
URI: http://eprints.goums.ac.ir/id/eprint/2551

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