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Natural inhibitors of PI3K/AKT signaling in breast cancer: Emphasis on newly-discovered molecular mechanisms of action

Safdari, Y. and Khalili, M. and Ebrahimzadeh, M.A. and Yazdani, Y. and Farajnia, S. (2015) Natural inhibitors of PI3K/AKT signaling in breast cancer: Emphasis on newly-discovered molecular mechanisms of action. Pharmacological Research, 93. pp. 314-318. ISSN 10436618

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Epidermal growth factor receptor (EGFR) plays a critical role in the initiation and progression of a variety of human cancers, including breast cancer. An important signaling pathway downstream of EGFR is the PI3K/AKt pathway, which regulates cellular processes as diverse as cell growth, survival, proliferation and migration. Deregulated activity of this pathway may lead to uncontrolled cell growth, survival, migration and invasion, contributing to tumor formation. In this review, we evaluate natural compounds that, in vitro (breast cancer cell lines) and/or in vivo (animal model, clinical) studies, suppress breast cancer cells or tumors mainly by suppressing the PI3K/AKT signaling pathway. The effect of these compounds on cell cycle arrest, inhibition of cell migration and invasion, tumor angiogenesis and metastasis in breast cancer are discussed. © 2014 Elsevier Ltd. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: 2 (2 difluoromethylbenzimidazol 1 yl) 4,6 dimorpholino 1,3,5 triazine; 2 benzoyl 3 phenyl 6,7 dichloroquinoxaline 1,4 dioxide; 2 4 (2 piperidinoethoxy)phenyl 3 phenyl 2h 1 benzopyran; alpelisib; antineoplastic agent; ascofuranone; Boswellia ovalifoliolata extract; everolimus; excisanin A; fenretinide; flavopiridol; grape seed extract; isoliquiritigenin; ll 202; melittin; naphtho1,2 bfuran 4,5 dione; natural product; oridonin; phosphatidylinositol 3 kinase inhibitor; plant extract; platycodin; protein kinase B inhibitor; quercetin; rpf 101; ry 10 4; silibinin; tehranolide; thymoquinone; unclassified drug; unindexed drug; wogonin, angiogenesis; antineoplastic activity; apoptosis; arachidonic acid metabolism; Article; Boswellia; Boswellia ovalifoliolata; breast cancer; breast cancer cell line; breast metastasis; cancer growth; cell cycle arrest; cell hypoxia; down regulation; G1 phase cell cycle checkpoint; human; MCF 7 cell line; mitochondrion; nonhuman; protein expression; signal transduction; tumor growth; tumor invasion
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 08:14
Last Modified: 16 Apr 2018 08:57
URI: http://eprints.goums.ac.ir/id/eprint/2534

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