Golestan University of Medical Sciences Repository

Endocrine gland abnormalities in thalassemia major: A brief review

Mohammadian, S. and Bazrafshan, H.R. and Sadeghi-Nejad, A. (2003) Endocrine gland abnormalities in thalassemia major: A brief review. Journal of Pediatric Endocrinology and Metabolism, 16 (7). pp. 957-964. ISSN 0334018X (ISSN)

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Thalassemia major (β-thalassemia) affects a significant segment of the population in certain areas of the world. Alterations in migration patterns have changed the geographic distribution of this disease and made it a worldwide health problem. Over the course of the past 2-3 decades hypertransfusion therapy has significantly increased the life expectancy, and improved the quality of life of these patients. At the same time there has been an increase in the frequency of complications of this therapy caused by iron overload. Endocrine gland abnormalities contributed little to the morbidity or mortality of β-thalassemia in the past. As a result of hypertransfusion therapy and increased longevity, however, endocrinopathies have become more common and contribute significantly to morbidity in these patients. In this article we briefly review the current understanding of endocrine gland abnormalities, primarily caused by iron overload, in patients with thalassemia major.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - J. Pediatr. Endocrinol. Metab. [Field not mapped to EPrints] C2 - 14513870 [Field not mapped to EPrints] AD - Department of Pediatrics, Golestan Univ. of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Div. of Pediatric Endocrinol./Metab., Tufts University School of Medicine, Tufts-New England Medical Center, 750 Washington Street, Boston, MA 02111, United States [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Beta-thalassemia, Delayed puberty, Diabetes mellitus, Endocrine failure, Endocrine gland, Iron toxicity, Short stature, Thalassemia major, deferoxamine, gonadorelin, hemoglobin, iron, somatomedin binding protein, somatomedin C, adrenal insufficiency, beta thalassemia, blood transfusion, chelation therapy, diabetes mellitus, endocrine disease, geography, growth hormone deficiency, growth retardation, human, hypogonadism, hypoparathyroidism, hypothyroidism, iron chelation, iron overload, life expectancy, morbidity, mortality, population migration, population research, quality of life, review, thalassemia major, Adrenal Insufficiency, beta-Thalassemia, Body Height, Child, Diabetes Mellitus, Endocrine System Diseases, Humans, Hypogonadism, Hypoparathyroidism, Hypothyroidism
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 19 Apr 2015 05:00
Last Modified: 16 Apr 2018 08:49
URI: http://eprints.goums.ac.ir/id/eprint/2476

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