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Relationship between malondialdehyde level and glutathione peroxidase activity in diabetic rats

Qujeq, D. and Aliakbarpour, H.R. and Kalavi, K. (2004) Relationship between malondialdehyde level and glutathione peroxidase activity in diabetic rats. Clinica Chimica Acta, 340 (1-2). pp. 79-83. ISSN 00098981 (ISSN)

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Abstract

Background: This investigation describes the relationship between glutathione peroxidase activities, an antioxidant enzyme, and the oxidative status in diabetic rat blood. Methods: Malondialdehyde level and glutathione peroxidase activity were measured by spectrophotometric techniques. Results and conclusions: Malondialdehyde content in the diabetic rats group was increased compared to that in the controls [3.08±0.32 (mean±S.E.) vs. 1.15±0.29 mmol/g hemoglobin, P>0.01]. Glutathione peroxidase activity in the diabetic rats group was increased compared to that in the control [10.27±1.39 (mean±S.E.) vs. 3.14±0.38 μmol NADPH/min/g hemoglobin, P>0.01]. Our results show a positive correlation between serum glutathione peroxidase and malondialdehyde concentration in diabetic rats. © 2003 Elsevier B.V. All rights reserved.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Clin. Chim. Acta [Field not mapped to EPrints] C2 - 14734198 [Field not mapped to EPrints] AD - Dept. of Biochemistry and Biophysics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran [Field not mapped to EPrints] AD - Department of Laboratory, Azad Islami University of Babol, Babol, Iran [Field not mapped to EPrints] AD - Department of Hematology, Faculty of Paramedicine, Gorgan Univ. of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Antioxidant enzyme, Diabetic, Glucose, Glutathione peroxidase activity, Malondialdehyde, Oxidative damage, Oxygen free radicals, Rat, glutathione peroxidase, hemoglobin, malonaldehyde, reduced nicotinamide adenine dinucleotide phosphate, animal model, article, controlled study, diabetes mellitus, enzyme activity, hemoglobin determination, male, nonhuman, priority journal, rat, spectrophotometry, Animals, Antioxidants, Blood Glucose, Body Weight, Diabetes Mellitus, Experimental, Glutathione Peroxidase, Male, Malondialdehyde, Oxidative Stress, Rats, Rats, Wistar, Spectrophotometry
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 03:33
Last Modified: 04 Feb 2017 11:07
URI: http://eprints.goums.ac.ir/id/eprint/2474

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