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Prevalence of goiter among schoolchildren from Gorgan, Iran, a decade after national iodine supplementation: Association with age, gender, and thyroperoxidase antibodies

Bazrafshan, H.R. and Mohammadian, S. and Ordookhani, A. and Farhidmehr, F. and Hedayati, M. and Abdolahi, N. and Azizi, F. and Braverman, L.E. and Pearce, E.N. (2005) Prevalence of goiter among schoolchildren from Gorgan, Iran, a decade after national iodine supplementation: Association with age, gender, and thyroperoxidase antibodies. Journal of Endocrinological Investigation, 28 (8). pp. 727-733. ISSN 03914097 (ISSN)

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Abstract

Background: One decade after universal salt iodization in Iran, goiter prevalence, urinary iodine concentration (UIC) and thyroperoxidase antibody (TPOAb) values were assessed among schoolchildren in Gorgan, Iran. Methods: From 2003-2004, 500 girls and 900 boys aged 7-11 yr were evaluated for goiter by palpation. UIC was measured in 183 randomly-selected goitrous children. Serum TSH, T 4, and TPOAb were measured in 53 goitrous and 30 non-goitrous children with adequate UIC. Results: Goiter was detected in 370 (26.4%) children. Goiter was present in 31 % of girls and 17% of boys age 9 (p<0.012); 37% of girls and 20% of boys age 10 (p<0.003); and 52% of girls and 19% of boys age 11 (p<0.0001). Median (range) UIC for all goitrous children sampled was 190 (20-600) μg/l; 220 (30-590) in boys and 170 (20-600) in girls (p=0.001). Eight point seven percent of goitrous children and 22% of goitrous girls aged 10-11 had UIC<100 μg/l, while 47% of the goitrous children had UIC≥200 μg/l. TPOAb was present in 52.8% of goitrous children and 10% of non-goitrous children (p=0.0001 ). TPOAb was present in 53.9% of 10-11 and 22.7% of 7-9 yr old goitrous and non-goitrous children (p=0.003) with adequate UIC. Median (range) TSH was 2.9 (0.3-10.9) mlU/l in TPO-positive and 1.8 (0.5-4.1) in TPO-negative children (p=0.001 ). Conclusions: Gorgan, Iran, is an iodine-sufficient area and almost half of schoolchildren have more than adequate UIC. TPOAb is associated with endemic goiter. Despite sufficient UIC overall, some school-aged girls remain at risk of iodine deficiency. ©2005, Editrice Kurtis.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - J. Endocrinol. Invest. [Field not mapped to EPrints] C2 - 16277169 [Field not mapped to EPrints] AD - Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Section of Endocrinology, Diabetes, and Nutrition, Boston University Medical Center, Boston, MA, United States [Field not mapped to EPrints] AD - Boston University Medical Center, 88 East Newton Street, Boston, MA 02118, United States [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Autoimmunity, Goiter, Iodine, Iran, Thyroid autoantibodies, enzyme antibody, iodine, thyroid peroxidase, thyrotropin, thyroxine, age distribution, article, controlled study, female, goiter, human, Iran, major clinical study, male, palpation, prevalence, school child, sex difference, supplementation, thyrotropin blood level, thyroxine blood level, Age Factors, Autoantibodies, Case-Control Studies, Child, Female, Goiter, Humans, Iodide Peroxidase, Iodine, Iran, Male, Prevalence, Sex Factors, Thyroglobulin, Thyrotropin, Thyroxine, Triiodothyronine
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 09:01
Last Modified: 05 Feb 2017 20:53
URI: http://eprints.goums.ac.ir/id/eprint/2459

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