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Altered pituitary hormone secretion in male rats exposed to Bisphenol A

Gharravi, A.M. and Ghorbani, R. and Khazaei, M. and Pour Motabbad, A. and Al Agha, M. and Ghasemi, J. and Sayadi, P. (2006) Altered pituitary hormone secretion in male rats exposed to Bisphenol A. Indian Journal of Occupational and Environmental Medicine, 10 (1). pp. 24-27. ISSN 09732284 (ISSN)

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Abstract

Bisphenol A (BPA) is a xenobiotic estrogenic compound. This compound has been suspected to have estrogenic effects on reproductive system of males and females. In this present study we investigated possible low-dose effects of BPAon Luteinizing Hormone in rats. Male Wistar rats (12-13 weeks old) were administrated a daily intra peritoneal 10 μg/kgbw/day, 50 μg/kgbw/day, 100 μg/kgbw/ day dose of BPA for 6, 6, and 12 days, and one day after last injection, serum level of Luteinizing Hormone was examined by ELISA method. All data were expressed as means ± SE. Two-way ANOVA was performed. Analysis of data showed that in all dose groups, plasma level of Luteinizing Hormone significantly decreased compared to control group. The present study showed that BPA at low doses affects Luteinizing Hormone, one of main hormones in spermatogenesis in the adult Wistar rats, and subsequently alters the steroidgenesis in testicular Leydig cells.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Indian J. Occup. Environ. Med. [Field not mapped to EPrints] AD - Department of Anatomy, School of Medicine, Gorgan University of Medical Sciences, Iran [Field not mapped to EPrints] AD - Department of Anatomy, School of Medicine, Kerman Shah University of Medical Science, Kerman Shah, Iran [Field not mapped to EPrints] AD - Department of Physiology, School of Medicine, Kerman Shah University of Medical Science, Kerman Shah, Iran [Field not mapped to EPrints] AD - Department of Pathology, School of Medicine, Kerman Shah University of Medical Science, Kerman Shah, Iran [Field not mapped to EPrints] AD - Department of Chemistry, School of Sciences, Razi University, Kerman Shah, Iran [Field not mapped to EPrints] AD - Department of Biophysics, School of Medicine, Kerman Shah University of Medical Science, Kerman Shah, Iran [Field not mapped to EPrints] AD - Department of Anatomy, Gorgan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Bisphenol A, Luteinizing hormone, Spermatogenesis, 4,4' isopropylidenediphenol, hypophysis hormone, luteinizing hormone, analysis of variance, article, blood level, controlled study, correlation analysis, data analysis, enzyme linked immunosorbent assay, hormone blood level, hormone release, Leydig cell, male, nonhuman, rat, rat strain, spermatogenesis
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 05:01
Last Modified: 06 Feb 2017 06:17
URI: http://eprints.goums.ac.ir/id/eprint/2455

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