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Effects of opium dependency on hypothalamic pituitary gonadal axis

Shahramian, I. and Moradi, A. and Roosta, L. and Rakhshani, M. and Moein, A.-A. and Shakeri, S. and Mansorian, A.-R. (2006) Effects of opium dependency on hypothalamic pituitary gonadal axis. Journal of Medical Sciences, 6 (2). pp. 209-212. ISSN 16824474 (ISSN)

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Abstract

The aim of this study was to determine the effect of opium on hypothalamic pituitary gonad function. Fifty-six opium dependent (28 men and 28 women; mean age, 25±5 year) were enrolled for hypothalamic pituitary gonadal axis. The control group considered of 56 non-opium dependent subject (28 men and 28 women; mean age 25±5 year). Decreased libido or impotency was present in 26 of 28 opium dependent men. The serum testosterone level was below 9 nmol L-1 in 24 of 28 men and was significantly lower than that in the control group (p<0.001). The free androgen index was below normal in 16 of 28 men and was significantly lower than that in the control group (p<0.001). The serum LH level was less than 2 U L-1 in 17 of 28 men significantly lower than that in the control group (p<0.001). Serum FSH was normal in both groups. Decreased libido was present in 16 of 28 women opium dependent. Serum LH, estradiol and progesterone levels were lower in opium group. In conclusion, of all opium addicts the large majority of men and all of women developed hypogonadotropic hypogonadism. The results reveal that opium can extract deleterious actions upon male and female hypothalamic pituitary gonadal axis and these findings suggested that further investigations are required to determine the need for endocrine work-up in opium dependent and the important substitutive therapy.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - J. Med. Sci. (Pakistan) [Field not mapped to EPrints] AD - Medical School, Zabol University of Medical Sciences, Zabol, Iran [Field not mapped to EPrints] AD - Medical School, Gorgan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Medical School, Shiraz University of Medical Sciences, Shiraz, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: FSH, Gonadal function, LH, Opium, Testosterone, androgen, estradiol, follitropin, luteinizing hormone, progesterone, testosterone, adult, article, controlled study, estradiol blood level, female, follitropin blood level, human, hypogonadotropic hypogonadism, hypothalamus hypophysis gonad system, impotence, libido disorder, luteinizing hormone blood level, major clinical study, male, opiate addiction, progesterone blood level, testosterone blood level
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 19 Apr 2015 04:37
Last Modified: 07 Feb 2017 08:44
URI: http://eprints.goums.ac.ir/id/eprint/2454

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