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Detection of HPV in cancerous and non-cancerous esophageal tissues from Turkmen-Sahra, Iran

Moradi, A. and Mokhtari-Azad, T. (2006) Detection of HPV in cancerous and non-cancerous esophageal tissues from Turkmen-Sahra, Iran. International Journal of Cancer Research, 2 (2). pp. 113-118. ISSN 18119727 (ISSN)

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The aim of this study were to assess the presence of HPV esophageal infection among Iranian Turkmen who live in an area located in the cancer belt in Asia. The specimens derived from 120 patients previously diagnosed for Squamous Cell Carcinoma (SCC) non-cancerous tissue derived from esophagus. All specimens were examined for the presence of HPV DNA PCR was utilized to amplify a 150 bp segment of HPV L1 gene using the consensus primers. The amplified region was subsequently sequenced to identify the HPV genotypes. The HPV DNA was detected in 49.4% of patients with SCC, and 58% of non-cancerous tissue of esophagus. The positive samples included HPV-16 (46.6%), HPV-6 (24.6%), HPV-66 (8.2%), HPV-52 (4.1%), HPV-18 (2.7%); 14% of cases were positive for more than one type of HPV. The results confirm the presence of HPV in both esophageal cancerous and non-cancerous tissues. These results imply two different interpretations: 1) Due to non-significant difference between the rate of HPV positive in cancerous and non-cancerous tissues, HPV has no important role in esophageal cancers, which is less probable. 2). Because of a highly incidence of esophageal cancer in Turkmen-Sahra region, the HPV is a possible etiologic agent in esophageal carcinogenesis, most probably acting synergistically with physical, chemical, and/or nutritional factors that have previously been found to be related to this malignancy in Turkmen-Sahra. © 2006 Academic Journals Inc., USA.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Int. J. Cancer Res. [Field not mapped to EPrints] AD - Department of Microbiology, Medical School, Gorgan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Virology, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Esophageal tissue, HPV, Iran, Turkmen-Sahra, eosin, hematoxylin, virus DNA, adult, aged, article, cancer incidence, DNA extraction, esophagitis, esophagus biopsy, esophagus cancer, female, gene amplification, gene identification, gene sequence, genome analysis, genotype, human, Human papillomavirus type 16, Human papillomavirus type 18, human papillomavirus type 52, Human papillomavirus type 6, Human papillomavirus type 66, human tissue, Iran, major clinical study, male, nonhuman, polymerase chain reaction, sequence analysis, sex difference, squamous cell carcinoma, virus carcinogenesis, virus detection, virus identification, Wart virus
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 05:06
Last Modified: 07 Feb 2017 06:48
URI: http://eprints.goums.ac.ir/id/eprint/2451

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