Golestan University of Medical Sciences Repository

Effect of haemodialysis on plasma lipid peroxidation and endogenous non-enzymic antioxidants in Gorgan (South East of Caspian Sea)

Marjani, A. (2006) Effect of haemodialysis on plasma lipid peroxidation and endogenous non-enzymic antioxidants in Gorgan (South East of Caspian Sea). Journal of Medical Sciences, 6 (4). pp. 681-685. ISSN 16824474 (ISSN)

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Abstract

The aim of this study was to evaluate the effect of haemodialysis on lipid peroxidation (the level of lipid peroxidation expressed as malondialdehyde) and endogenous non-enzymic antioxidants before and after the dialysis and compared with control group. The sampling procedure was a purposive sampling. Twenty two patients with Chronic Renal Failure (CRF) disease who were haemodialysed at 5th Azar hospital of Gorgan Dialysis Center (2005). Twenty two age and sex matched healthy control were recruited for this study. Plasma level of malondialdehyde and uric acid were significantly increased and reduced in the postdialysis group when compared with predialysis and control group, respectively (p<0.001). The plasma level of albumin and total bilirubin were significantly increased in postdialysis group when compared with predialysis group (p<0.001). The increasing level of plasma lipid peroxidation and the significant difference of non-enzymic antioxidants in the haemodialyzed patients after the process of dialysis, maybe related with the patient uremia, the quality of consumed water in the dialysis procedure, dialysis membrane and the loss of these antioxidants through membranes and hemoconcentration of them during the dialysis process and the dialysis process (may increase lipid peroxidation during the dialysis process). These states of affairs may play an important role in progress of cardiovascular abnormality in haemodialyzed patients. Due to this conditions a review of haemodialysis membrane, the techniques used in the dialysis, the consumption of various oral antioxidant, the elimination of active oxygens from the dialysis surrounding are among the measures which can prevent sudden cardiovascular abnormality in the haemodialysis patients and ultimately these important factors up- grade the patients quality of life and prevent sudden silent myocardial infarction.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - J. Med. Sci. (Pakistan) [Field not mapped to EPrints] AD - Department of Biochemistry and Biophysic, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Endogenous nonenzymic antioxidants, Haemodialysis, Lipid peroxidation, albumin, antioxidant, bilirubin, malonaldehyde, uric acid, adult, albumin blood level, article, bilirubin blood level, cardiovascular disease, chronic kidney failure, clinical article, controlled study, dialysis membrane, female, hemoconcentration, hemodialysis, hemodialysis patient, human, Iran, lipid peroxidation, male, pathophysiology, purposive sample, quality of life, silent myocardial infarction, statistical significance, uremia, uric acid blood level, water quality
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 19 Apr 2015 04:12
Last Modified: 07 Feb 2017 08:36
URI: http://eprints.goums.ac.ir/id/eprint/2448

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