Golestan University of Medical Sciences Repository

Chronic effect of the hydroalcholic extract of Urtica dioica leaves on regeneration of β-cells of hyperglycemic rats

Golalipour, M.J. and Khori, V. and Ghafari, S. and Gharravi, A.M. (2006) Chronic effect of the hydroalcholic extract of Urtica dioica leaves on regeneration of β-cells of hyperglycemic rats. Pakistan Journal of Biological Sciences, 9 (8). pp. 1482-1485. ISSN 10288880 (ISSN)

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Abstract

Urtica dioica has been introduced with hypoglycemic activity in Iranian traditional medicine. There are some reports with different results about the hypoglycemic activity of Urtica dioica. This study was done to determine the chronic effect of the hydroalcholic extract of Urtica dioica leaves on Hyperglycemia and regeneration of β-cells in hyperglycemic rats. 30 Wistar rats were allocated in groups of normal, Diabetic and treatment. Hyperglycemia in Rats induced by 80 mg kg-1 streptozotocin. One week after injection of STZ Animals in treatment group received hydroalcholic extract of Urtica dioica 100 mg kg-1 day-1 for 4 weeks, intraperitoneally. The blood glucose was measured by using a Glucometer in 1st, 3rd and 5th weeks. In the end of 5th weeks the animals in each group were sacrificed by ether anesthesia and whole pancreas in three groups extracted and fixed in bouin and stained by chrome alum hematoxiline-phloxine stain and beta cells percentage were counted in three groups by Olympus microscope. Mean±SE of blood glucose concentrations in end of fifth weeks were 99.4±5.0, 454.7±34.5 and 447.4±42.5 in control, diabetic and treatment groups, respectively (p<0.05).The percentage of β-cells (beta cells) in control, diabetic and treatment groups was 73.6, 1.9 and 1.3, respectively. The percentage of β-cells in diabetic and treatment groups comparing with control group was significant (p<0.05). This study showed that chronic administration of hydroalcholic extract of Urtica dioica has not hypoglycemic effect and regeneration of β-cells of langerhans in hyperglycemic rats. © 2006 Asian Network for Scientific Information.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Pak. J. Biol. Sci. [Field not mapped to EPrints] AD - Department of Embryology and Histology, Gorgan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Pharmacology, Gorgan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Histology and Embryology, Gorgan University of Medical Sciences, P.O. Box 49175-553, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: β-cells, Hyperglycemia, Streptozotocin, Urtica dioica, Animalia, Rattus norvegicus, Urtica dioica
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 09:02
Last Modified: 06 Feb 2017 07:52
URI: http://eprints.goums.ac.ir/id/eprint/2446

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