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Detection of human papillomavirus DNA in intraosseus ameloblastoma

Mokhtari-Azad, T. and Moradi, A. and Khodayari-Nemin, A. and Reza Keikhaee, M. and Sargolzaei, S. and Shahrokhi, M. (2006) Detection of human papillomavirus DNA in intraosseus ameloblastoma. International Journal of Virology, 2 (1). pp. 1-6. ISSN 18164900 (ISSN)

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Abstract

Human Papillomavirus (HPV) infection has been shown as a risk factor in oral carcinogenesis. The association between HPV and benign and malignant neoplasm of oral mucosa, especially surface epithelium-derived tumors, is well established. The role of HPV in pathogenesis of odontogenic cysts and tumors has been published in few articles. The aim of this study was detection of HPV in Iranian patients with intrabony ameloblastoma and investigation of specific risk factors associated with ameloblastoma. One hundred intrabony ameloblastoma and 50 age-sex matched samples as controls were evaluated by polymerase chain reaction for the detection and typing of HPV. Fisher exact and chi square tests were used to assess the data. HPV DNA was detected in 32% of patients and 10% of controls. HPV-6 was the most prevalent genotype (31.6%) in infected cases. It was followed by HPV-11 (12.5%), HPV-16 (12.5%) and HPV-31 (3.1%). We found a significant association between presence of HPV and location of tumor (p = 0.02), traumatic history (p = 0.03) and ododontic therapy (p = 0.01). These findings indicated that HPV-6 probably is one of the most important etiologic agents in causing intraosseous ameloblastoma in Iranian population. © 2006 Academic Journals Inc., USA.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Int. J. Virol. [Field not mapped to EPrints] AD - Department of Virology, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Department of Microbiology, Medical School, Gorgan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Oral and Maxillofacial Surgery, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Genetic Research Center, Welfare and Rehabilitation University, Tehran, Iran [Field not mapped to EPrints] AD - Department of Oral and Maxillofacial Pathology, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Ameloblastoma, Human papillomavirus, Iran, PCR, Risk factors, virus DNA, adolescent, adult, ameloblastoma, article, chi square test, controlled study, correlation analysis, disease association, DNA extraction, endodontics, female, Fisher exact test, gene amplification, genotype, human, Human papillomavirus type 11, Human papillomavirus type 16, human papillomavirus type 31, Human papillomavirus type 6, human tissue, injury, Iran, major clinical study, male, mandible tumor, maxilla tumor, nonhuman, Papilloma virus, polymerase chain reaction, prevalence, risk factor, tumor localization, virus carcinogenesis, virus detection, virus typing, Wart virus, Human papillomavirus, Human papillomavirus type 16
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 05:27
Last Modified: 07 Feb 2017 06:58
URI: http://eprints.goums.ac.ir/id/eprint/2434

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